Showing papers by "Kenneth D. Brandt published in 2016"
TL;DR: NFAT1 is a transcriptional regulator of multiple anabolic and catabolic genes in AC of aged mice and Epigenetically mediated reduction of NFAT1 expression causes imbalanced metabolic activities of articular chondrocytes in aged mice.
24 citations
01 Jan 2016
TL;DR: A 23-year-old woman with psoriasis developed lupus erythematosus during treatment with psoralen-ultraviolet-A (PUVA) as mentioned in this paper.
Abstract: Systemic lupus erythematosus (SLE) developed in a 23-year-old woman with psoriasis during treatment with psoralen-ultraviolet-A (PUVA). The connective tissue disease was characterized by an erythematous rash, hair loss, nephritis, splenomegaly, seizures, and coma. Serum antinuclear antibodies were present in high titer, and hypocomplementemia developed. Antibodies to native or ultraviolet-irradiated DNA were not demonstrated. While the association of psoriasis and lupus may have been fortuitous, the temporal relationships suggest that PUVA treatment in this case may have been of pathogenetic importance in the development of the connective tissue disease. (Arch Dermatol 115:54-56, 1979)