K
Kenneth D. Kopple
Researcher at GlaxoSmithKline
Publications - 1
Citations - 5191
Kenneth D. Kopple is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Bioavailability & Polar surface area. The author has an hindex of 1, co-authored 1 publications receiving 3896 citations.
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Molecular properties that influence the oral bioavailability of drug candidates.
Daniel F. Veber,Stephen R. Johnson,Hung-Yuan Cheng,Brian R. Smith,Keith W. Ward,Kenneth D. Kopple +5 more
TL;DR: Reduced molecular flexibility, as measured by the number of rotatable bonds, and low polar surface area or total hydrogen bond count are found to be important predictors of good oral bioavailability, independent of molecular weight.