K
Kersti K. Linask
Researcher at University of South Florida
Publications - 33
Citations - 1252
Kersti K. Linask is an academic researcher from University of South Florida. The author has contributed to research in topics: Wnt signaling pathway & Heart development. The author has an hindex of 19, co-authored 33 publications receiving 1167 citations. Previous affiliations of Kersti K. Linask include University of Medicine and Dentistry of New Jersey & University of Pennsylvania.
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Precardiac cell migration: Fibronectin localization at mesoderm-endoderm interface during directional movement
Kersti K. Linask,James W. Lash +1 more
TL;DR: The correlations between FN distribution at the mesoderm-endoderm interface and directional cell movement suggest that the precardiac cells may migrate by haptotaxis, i.e., by moving along the substratum toward areas of greater adhesiveness.
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Doppler Echocardiography of Normal and Abnormal Embryonic Mouse Heart
TL;DR: Echocardiographic data can now be obtained beginning at d 11 in the mouse embryo for analyses relating to abnormal heart development, and Qualitative markers of embryonic congestive heart failure such as valvular regurgitation may be present and detectable with structuralValvular abnormalities or failing cardiac physiology.
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Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate
TL;DR: Folic acid supplementation alone or with myoinositol prevented alcohol potentiation of Wnt/beta-catenin signaling that allowed normal gene activation and cardiogenesis.
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Early heart development: Dynamics of endocardial cell sorting suggests a common origin with cardiomyocytes
Kersti K. Linask,James W. Lash +1 more
TL;DR: It is suggested that endocardial and myocardial cells may arise from a common precursor population and that N‐cadherin regulation may be a mechanism underlying specific cell sorting of these two cell populations during heart development.
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Cardiac morphogenesis: matrix metalloproteinase coordination of cellular mechanisms underlying heart tube formation and directionality of looping.
TL;DR: The experimental observations suggest that MMP activity regulates the coordination of early heart organogenesis by affecting ventral closure of the heart and gut tubes, asymmetric cell proliferation in the dorsal mesocardium to drive looping direction, and ECM degradation within the dorsal Mesocardium allowing looping to proceed toward completion.