The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors, Cushing's disease/syndrome, and other conditions.

Somatostatin-dopamine chimeric analogs

A catalyst unit suitable for loading into a tube in a reactor is described comprising a plurality of catalyst particles incorporated within a removable solid matrix, said unit in the form of an elongate body in which the particles are packed together such that the volume shrinkage upon removal of the removable matrix is ≤20%. The catalyst particles preferably comprise one or more metals selected from the group consisting of Fe, Ni, Co and Cu in oxidic or reduced form. The units are particularly suitable for loading catalyst into tubes in a Fischer-Tropsch reactor.

Shaped catalyst units

The invention relates to a novel stereoselective process for the preparation of dihdyrolysergol from lysergol by hydrogenation in the presence of solvent and palladium catalyst applied on a carrier, which comprises hydrogenating lysergol in the presence of one or more aprotic solvent(s) containing tertiary nitrogen atom(s) and a palladium catalyst applied on activated carbon, and recovering the product obtained from the reaction mixture in a known manner.

Steroselective hydrogenation process

The invention relates to a Raney catalyst composition which comprises ice as a solid carrier. Portions of a Raney catalyst containing ice as solid carrier are added stepwise to the reaction mixture. The vessel 1 used for the storage and/or handling of the Raney catalyst has a conic casing or side walls 2 joining to the bottom 4 through a bend radius 3 of greater than 0.5 mm size. The vessel 1 is covered by a tightly closing cap 5.

Raney catalyst composition and vessel for containing same

A Raney catalyst composition which has ice as a solid carrier. The reaction involving the Raney catalyst of the invention is carried out by portionwise adding a Raney catalyst containing ice as solid carrier to the reaction mixture. The operation-safe cylindrical or angular vessel used for the storage and/or handling of the Raney catalyst has a conical casing or side walls joining to the bottom through a bend radius of greater than 0.5 mm. The vessel is covered by a tightly closing cap.

Reliable raney catalyst composition and vessel for containing same

L'invention a pour objet une composition de catalyseur de Raney exempte de danger qui comprend, en tant que support solide, de la glace. La reaction impliquant le catalyseur de Raney selon la presente invention est mise en œuvre par addition, par parties, au melange reactionnel d'un catalyseur de Raney contenant un support solide forme de glace. Le recipient 1 utilise pour le stockage et/ou la manipulation du catalyseur de Raney est conique et est forme de parois laterales 2 inclinees, d'une partie de paroi courbe 3 presentant un rayon de courbure de 0,5 mm et d'un fond 4. Le recipient 1 est ferme par un couvercle etanche 5.

Kiss Janos

Papers

Steroselective hydrogenation process

Raney catalyst composition and vessel for containing same

Reliable raney catalyst composition and vessel for containing same

Composition de catalyseur de raney exempte de danger et recipient la contenant.