Showing papers by "Klaus Albert published in 1984"
TL;DR: In this paper, the design of a probehead for continuous-flow 13C NMR spectroscopy is described and the sensitivity and resolution presently available demonstrated, and a comparison of static continuous flow measurements shows that continuous flow NMR can be advantageously employed for studying reaction kinetics and for monitoring the separation of complex 13C-labelled product mixtures by direct coupling with high performance liquid chromatography.
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TL;DR: The results presented demonstrate that non-invasive and non-radio-active real time monitoring of drug metabolism in intact organs is possible.
Abstract: Continuous flow 13C NMR spectroscopy has been used for the first time to monitor the metabolism of a 13C labeled drug in an isolated liver Continuous and almost immediate information on the metabolite formation could be obtained using 13C labeled phenacetin without alteration of the biological system The data are consistent with those observed by conventional techniques (HPLC, aliquot 13C NMR measurements) From the biological point of view the sensitivity of continuous flow 13C NMR spectroscopy is still low (10(-3) M) The results presented demonstrate however that non-invasive and non-radioactive real time monitoring of drug metabolism in intact organs is possible
11 citations
TL;DR: In this paper, an investigation of the alkaloidal constituents of the leaves of Catharanthus roseus has led to the isolation of a new alkaloid, "rosicine", to which structure (1) has been assigned on the basis of spectroscopic studies.
6 citations