From the combination of knowledge and actions, someone can improve their skill and ability. It will lead them to live and work much better. This is why, the students, workers, or even employers should have reading habit for books. Any book will give certain knowledge to take all benefits. This is what this the interferon system tells you. It will add more knowledge of you to life and work better. Try it and prove it.

The Interferon System

Antitumor effects of interferon.

On the varied biologic effects of interferon

A viral inhibitor(s) is released in the supernate of mixed cultures containing human or mouse lymphocytes and cells from certain lines. The inhibitor is active against a variety of unrelated viruses and is a protein that is not toxic for cells. It does not inactivate viruses directly, but inhibits viral replication through an intracellular mechanism that involves synthesis by the cells of both RNA and protein. These characteristics identify the inhibitor as an interferon. The anti-viral activity is contained in at least two molecular species, of approximately 25,000 and 45,000 daltons, respectively. In addition to the anti-viral activity, the supernates of the mixed cultures display an anti-cellular activity, the inhibition of DNA synthesis and of cell multiplication. The anti-viral and the anti-cellular activities are positively correlated in supernates from various cultures and in partially purified preparations. The human cell population responsible for interferon production is composed mainly of Fc-receptor positive, surface immunoglobulin negative, non-T-cell lymphocytes. The ability of certain cell lines to induce interferon seems to be preferentially associated with tumor origin or with in vitro transformation by certain viruses (Epstein-Barr virus, murine sarcoma virus).

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Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Identification of the anti-viral activity as interferon and characterization of the human effector lymphocyte subpopulation.

The human interferons--from protein purification and sequence to cloning and expression in bacteria: before, between, and beyond.

IT has been shown repeatedly that preparations of mouse interferon inhibit the growth of mouse cells in vitro1–4 In addition to inducing the antiviral state and inhibiting cell growth, preparations of mouse interferon stimulate interferon production by priming5, enhance phagocytic activity6, and potentiate in cells the toxic effect of double-strand ed RNA7. All attempts with preparations of mouse interferon to separate the antiviral activity from the non-antiviral activities have been unsuccessful3,5,8. With human interferon few experiments have been reported, although the data available indicate inhibition of growth by preparations of human leukocyte interferon9–11. It has been claimed that the antiviral and cell growth inhibitory activities of human leukocyte interferon reside in different molecules and can be separated from each other by certain methods of fractionation12. In a more recent report13, however, separation of the two activities could not be demonstrated even in drastic denaturing conditions. I have shown that both the antiviral and the cell growth inhibitory activity of human fibroblast interferon reside in the same glycoprotein.

Knight E

Papers

Antiviral and cell growth inhibitory activities reside in the same glycoprotein of human fibroblast interferon.