Koji Kasanuki

TL;DR: The current knowledge of CSF1R-related leukoencephalopathy is addressed and the putative pathophysiology is discussed, with a focus on microglia, as well as future research directions.

TL;DR: A conceptual framework is proposed to identify these symptomatic but non‐demented individuals that led to suspect the underlying pathophysiology of Lewy body disease and further prospective study is warranted to determine the clinical significance of LB‐related symptoms in non‐Demented patients.

TL;DR: Paying attention to non-motor symptoms of PD may help DLB diagnosis in the early stage, especially in terms of its differentiation from AD.

TL;DR: It is suggested that amyloid deposition may contribute to the timing of the onset of dementia relative to that of parkinsonism in Lewy body dementia.

TL;DR: Investigation of potential neuropathologic and biochemical alterations of autophagy-lysosome pathway-related proteins in the brains of patients with dementia with Lewy bodies, Alzheimer disease, and control subjects using antibodies against Ras-related protein Rab-7B finds specific accumulation of the autophagosomal LC3-II isoform in detergent-insoluble fractions from DLB brains.