Aberrant or defective immune responses are known to be the result of primary immunodeficiency diseases, e.g., in the DiGeorge syndrome (thymic hypoplasia) in man, or in homozygous mice with the mut...

https://www.tandfonline.com/doi/pdf/10.1080/15476910701508262

Immune suppression as related to toxicology.

Pollution-associated diseases and abnormalities of fish and shellfish: a review.

Seventeen desert tortoises, Xerobates agassizii, with upper respiratory tract disease were examined; thirteen were euthanatized for necropsy. Four normal control desert tortoises from a clinically healthy population were similarly evaluated. Hemoglobin and phosphorus values were significantly (P ≤ 0.05) lower and serum sodium, urea, SGOT, and cholesterol values were significantly higher in ill tortoises compared to controls. No significant differences in concentrations of serum or liver vitamins A and E were found between the two groups. While no significant differences were found for concentrations of lead, copper, cadmium, and selenium, the livers of ill tortoises had higher concentrations of mercury and iron. Lesions were found consistently in the upper respiratory tract (URT) of ill tortoises. In all ill tortoises dense infiltrates of lymphocytes and histiocytes obscured the mucosal epithelium and underlying glands. The mucosal epithelium was variably dysplastic, hyperplastic, and occasionally ulcerat...

https://bioone.org/journals/journal-of-wildlife-diseases/volume-27/issue-2/0090-3558-27.2.296/CHRONIC-UPPER-RESPIRATORY-TRACT-DISEASE-OF-FREE-RANGING-DESERT-TORTOISES/10.7589/0090-3558-27.2.296.pdf

Chronic upper respiratory tract disease of free-ranging desert tortoises (xerobates agassizii)

An overview of immunotoxicology and carcinogenic polycyclic aromatic hydrocarbons

This review evaluates the available information on the effects of mainstream and environmental tobacco smoke on the immune system in animals and humans. The primary emphasis is on mainstream smoke ...

Effects of mainstream and environmental tobacco smoke on the immune system in animals and humans: a review.

Rabbits given lead acetate, cadmium chloride, or mercuric chloride in their drinking water for 70 days and then inoculated with pseudorabies virus (3 doses, 7 days between doses) as antigen had significantly lower neutralizing antibody titers than did the controls. The titers were determined by the plaque assay method using serum samples prepared 7 (experimental day 78) and 24 (experimental day 95) days after the first viral innoculation was given.

Koller Ld

Papers

Immunosuppression produced by lead, cadmium, and mercury.