Metallic biomaterials are engineered systems designed to provide internal support to biological tissues and they are being used largely in joint replacements, dental implants, orthopaedic fixations and stents. Higher biomaterial usage is associated with an increased incidence of implant-related complications due to poor implant integration, inflammation, mechanical instability, necrosis and infections, and associated prolonged patient care, pain and loss of function. In this review, we will briefly explore major representatives of metallic biomaterials along with the key existing and emerging strategies for surface and bulk modification used to improve biointegration, mechanical strength and flexibility of biometals, and discuss their compatibility with the concept of 3D printing.

Metallic Biomaterials: Current Challenges and Opportunities.

The focus in the field of biomedical engineering has shifted in recent years to biodegradable polymers and, in particular, polyesters. Dozens of polyester-based medical devices are commercially available, and every year more are introduced to the market. The mechanical performance and wide range of biodegradation properties of this class of polymers allow for high degrees of selectivity for targeted clinical applications. Recent research endeavors to expand the application of polymers have been driven by a need to target the general hydrophobic nature of polyesters and their limited cell motif sites. This review provides a comprehensive investigation into advanced strategies to modify polyesters and their clinical potential for future biomedical applications.

Biomedical Applications of Biodegradable Polyesters.

Three-dimensional (3D) printing enables the production of anatomically matched and patient-specific devices and constructs with high tunability and complexity. It also allows on-demand fabrication with high productivity in a cost-effective manner. As a result, 3D printing has become a leading manufacturing technique in healthcare and medicine for a wide range of applications including dentistry, tissue engineering and regenerative medicine, engineered tissue models, medical devices, anatomical models and drug formulation. Today, 3D printing is widely adopted by the healthcare industry and academia. It provides commercially available medical products and a platform for emerging research areas including tissue and organ printing. In this review, our goal is to discuss the current and emerging applications of 3D printing in medicine. A brief summary on additive manufacturing technologies and available printable materials is also given. The technological and regulatory barriers that are slowing down the full implementation of 3D printing in the medical field are also discussed.

https://iopscience.iop.org/article/10.1088/1758-5090/aa7279/pdf

Current and emerging applications of 3D printing in medicine.

https://espace.library.uq.edu.au/view/UQ:276b006/UQ276b006_OA.pdf

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review.

Since the advent of additive manufacturing, known commonly as 3D printing, this technology has revolutionized the biofabrication landscape and driven numerous pivotal advancements in tissue engineering and regenerative medicine. Many 3D printing methods were developed in short course after Charles Hull first introduced the power of stereolithography to the world. However, materials development was not met with the same enthusiasm and remained the bottleneck in the field for some time. Only in the past decade has there been deliberate development to expand the materials toolbox for 3D printing applications to meet the true potential of 3D printing technologies. Herein, we review the development of biomaterials suited for light-based 3D printing modalities with an emphasis on bioprinting applications. We discuss the chemical mechanisms that govern photopolymerization and highlight the application of natural, synthetic, and composite biomaterials as 3D printed hydrogels. Because the quality of a 3D printed construct is highly dependent on both the material properties and processing technique, we included a final section on the theoretical and practical aspects behind light-based 3D printing as well as ways to employ that knowledge to troubleshoot and standardize the optimization of printing parameters.

Photopolymerizable Biomaterials and Light-Based 3D Printing Strategies for Biomedical Applications.

Appropriate selection of the implant biomaterial is a key factor for long term success of implants. The biologic environment does not accept completely any material so to optimize biologic performance, implants should be selected to reduce the negative biologic response while maintaining adequate function. Every clinician should always gain a thorough knowledge about the different biomaterials used for the dental implants. This article makes an effort to summarize various dental bio-materials which were used in the past and as well as the latest material used now.

Implant biomaterials: A comprehensive review.

Temporomandibular disorders (TMD) are clinical manifestations of disorders causing pain and dysfunction in the Temporomandibular Joints (TMJs) and masticatory muscles. TMJ abnormalities cannot be reliably assessed by a clinical examination.Radiographic examination forms an integral component for the routine assessment in patients with temporomandibular joint disorders. Latest imaging modality is making life easy for those clinicians who must evaluate the hard and the soft tissue of the temporomandibular joint complex in patients with TMDs. Conventional radiographic TMJ projections like transpharyngeal, transcranial, panoramic radiograph, conventional tomographic sections of TMJ may be adequate in number of clinical situations but there are bony alterations that occur in these disorders like erosions, osteophytes, pneumatisation of articular eminence that are difficult to be detected in the conventional radiographs due to overlapping of anatomical structures. So the advanced imaging techniques such as MRI, Ultrasonography, CBCTare required for the understanding of diseases of Temporomandibular Joint.This paper aims to cover all the latest imaging modalities that can be helpful in the diagnosis of Temporomandibular Joint Disorders.

/pdf/insights-of-tmj-through-advanced-imaging-4bdfi6b1hv.pdf

Krati Jain

Papers

Implant biomaterials: A comprehensive review.

Insights of TMJ through advanced imaging

The Ominous Aspergillus: A Case of Invasive Aspergillosis and Epitheloid Angiosarcoma of the Lung