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Krishnasamy Gunasekaran

Researcher at University of Madras

Publications -  46
Citations -  348

Krishnasamy Gunasekaran is an academic researcher from University of Madras. The author has contributed to research in topics: Virtual screening & Docking (molecular). The author has an hindex of 9, co-authored 43 publications receiving 221 citations.

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Structural modeling, in vitro antiproliferative activity, and the effect of substituents on the DNA fastening and scission actions of heteroleptic copper(II) complexes with terpyridines and naproxen

TL;DR: A series of heteroleptic copper(II) complexes of the type [Cu(L1-6)(nap)Cl] (1,6) (L 1-6 = 4′-(4-substituted)-2,2-:6′,2′′-terpyridines, nap = naproxen) has been synthesized and characterized as discussed by the authors.
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Structure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15

TL;DR: Attempts were made to identify inhibitors of an endoribonuclease of SARS-CoV-2, which is expected to play a crucial role in replication and all the compounds show significant interactions for tight binding.
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Antioxidant and Anticancer Activities of Methanol Extract of Seeds of Datura stramonium l

TL;DR: In this article, the authors investigated the antioxidant and antiproliferative activities of methanol extract of seeds of D. stramonium and found the presence of compounds with Rf values of 0.76, 0.58 and 0.36 at 500 μg/mL concentration respectively.
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Identification of potential PKC inhibitors through pharmacophore designing, 3D-QSAR and molecular dynamics simulations targeting Alzheimer's disease.

TL;DR: Present study corroborates the pharmacophore-based virtual screening, and finds the compound 6F as a potent Inhibitor of PKC, having therapeutic potential for Alzheimer’s disease.
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Biomimetic strategies to design metallic proteins for detoxification of hazardous heavy metal.

TL;DR: In this article, the authors developed a third generation biological tool for the removal of heavy metal (copper) from the effluent through the biosynthesis of intracellular and surface displayed metallic proteins with novel metal co-ordination chemistry.