K
Kristin M. Hardy
Researcher at California Polytechnic State University
Publications - 15
Citations - 280
Kristin M. Hardy is an academic researcher from California Polytechnic State University. The author has contributed to research in topics: Skeletal muscle & Anaerobic exercise. The author has an hindex of 9, co-authored 14 publications receiving 239 citations. Previous affiliations of Kristin M. Hardy include University of North Carolina at Wilmington.
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The long and winding road: influences of intracellular metabolite diffusion on cellular organization and metabolism in skeletal muscle.
TL;DR: The effect of diffusion distance on O(2) flux in muscle has been the subject of quantitative analyses for a century, but the influence of ATP diffusion from mitochondria to cellular ATPases on aerobic metabolism has received much less attention as discussed by the authors.
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A skeletal muscle model of extreme hypertrophic growth reveals the influence of diffusion on cellular design
TL;DR: Reaction-diffusion mathematical models demonstrate that diffusion would greatly constrain the rate of metabolic processes without these developmental changes in fiber structure.
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Gene transcripts encoding hypoxia-inducible factor (HIF) exhibit tissue- and muscle fiber type-dependent responses to hypoxia and hypercapnic hypoxia in the Atlantic blue crab, Callinectes sapidus.
Kristin M. Hardy,Chandler R. Follett,Louis E. Burnett,Louis E. Burnett,Sean C. Lema,Sean C. Lema +5 more
TL;DR: In crustaceans the HIF response to H and HH appears to involve changes in hif transcript abundance, with variation in h if-α and arnt/hif-β transcriptional dynamics occurring in both a tissue- and muscle fiber type-dependent manner.
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The metabolic demands of swimming behavior influence the evolution of skeletal muscle fiber design in the brachyuran crab family Portunidae
TL;DR: This work investigates the influence of intracellular diffusion on muscle fiber design in several swimming and non-swimming brachyuran crabs and demonstrates cellular responses to diffusion that were necessary for the evolution of swimming and are likely to be broadly applicable.
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Does intracellular metabolite diffusion limit post-contractile recovery in burst locomotor muscle?
TL;DR: It is concluded that fiber SA:V and O2 flux exert more control than intracellular metabolite diffusive flux over the developmental changes in metabolic organization and metabolic fluxes that characterize these muscles.