S
Sean C. Lema
Researcher at California Polytechnic State University
Publications - 66
Citations - 2498
Sean C. Lema is an academic researcher from California Polytechnic State University. The author has contributed to research in topics: Cyprinodon nevadensis & Population. The author has an hindex of 25, co-authored 60 publications receiving 2214 citations. Previous affiliations of Sean C. Lema include National Marine Fisheries Service & University of North Carolina at Wilmington.
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Journal ArticleDOI
Neural defects and cardiac arrhythmia in fish larvae following embryonic exposure to 2,2′,4,4′-tetrabromodiphenyl ether (PBDE 47)
TL;DR: Exposure to PBDE 47 can cause morphological abnormalities, impair cardiovascular function and cerebrospinal fluid flow, and provides a tractable starting point for using the zebrafish model to explore molecular mechanisms of PBDE toxicity.
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Dietary Exposure to 2,2´,4,4´-Tetrabromodiphenyl Ether (PBDE-47) Alters Thyroid Status and Thyroid Hormone–Regulated Gene Transcription in the Pituitary and Brain
TL;DR: The results indicate that dietary exposure to PBDE-47 alters TH signaling at multiple levels of the hypothalamic-pituitary-thyroid axis and provide evidence that TH-responsive pathways in the brain may be particularly sensitive to disruption by PBDE flame retardants.
Journal ArticleDOI
Adaptive Divergence in the Thyroid Hormone Signaling Pathway in the Stickleback Radiation
Jun Kitano,Jun Kitano,Jun Kitano,Sean C. Lema,Sean C. Lema,J. Adam Luckenbach,Seiichi Mori,Yui Kawagishi,Makoto Kusakabe,Makoto Kusakabe,Penny Swanson,Catherine L. Peichel +11 more
TL;DR: Changes in the thyroid hormone signaling pathway in stream-resident ecotypes of threespine stickleback fish, which have repeatedly evolved from ancestral marine ecotypes, indicate that evolutionary changes in hormonal signaling have played an important role in the postglacial adaptive radiation of sticklebacks.
Journal ArticleDOI
Forecasting the impacts of chemical pollution and climate change interactions on the health of wildlife.
Pamela D. Noyes,Sean C. Lema +1 more
TL;DR: This article summarized what is currently known about the potential reciprocal effects of climate change and chemical toxicity on wildlife, and depict current ap- proaches and ongoing challenges for incorporating climate effects into chemical testing and assessment.
Journal ArticleDOI
Low level exposure to the flame retardant BDE-209 reduces thyroid hormone levels and disrupts thyroid signaling in fathead minnows.
TL;DR: Effects at the low dose were consistent with the high dose, suggesting nonlinear relationships between BDE-209 exposures and thyroid dysfunction, and elevated the relative mRNA expression of genes encoding deiodinases, nuclear thyroid receptors, and membrane transporters in the brain and liver in patterns that varied with time and dose.