K
Kunio Kado
Researcher at Nagasaki University
Publications - 12
Citations - 439
Kunio Kado is an academic researcher from Nagasaki University. The author has contributed to research in topics: Gel electrophoresis & Sephadex. The author has an hindex of 7, co-authored 12 publications receiving 434 citations.
Papers
More filters
Journal ArticleDOI
Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect.
Tadashi Yoshimoto,Kunio Kado,Futoshi Matsubara,Nobuhiro Koriyama,Hiroshi Kaneto,Daisuke Tsuru +5 more
TL;DR: The results suggest the possibility that the inhibitors exhibit their anti-amnesic effect through the regulation of the enzyme activity in the brain through theregulation of the prolyl endopeptidase.
Journal ArticleDOI
CPT-11 Converting Enzyme from Rat Serum : Purification and Some Properties
TL;DR: Kinetic analysis revealed that the deacylation of the enzyme is the rate-limiting step in substrate hydrolysis, and this enzyme was found to also split other ester derivatives of SN-38 besides CPT-11.
Journal ArticleDOI
Purification and characterization of L-pyrrolidonecarboxylate Peptidase from Bacillus amyloliquefaciens.
TL;DR: The purified enzyme split amide and ester linkages in L-pyroglutamyl derivatives of L-alanine, beta-naphthylamine, alpha- naphthol, and 4-methylumbelliferone, but was completely inert towards various peptides and esters used as substrates for usual amino- and carboxy-peptidase, and for endopeptidases such as trypsin, subtilisin and alpha-
Journal ArticleDOI
Comparison of inhibitory effects of prolinal-containing peptide derivatives on prolyl endopeptidases from bovine brain and Flavobacterium.
TL;DR: The inhibitory effects of proline-containing peptides and their derivatives on prolyl endopeptidases from Flavobacterium meningosepticum and bovine brain were compared and suggest that there are some structural differences in the S2 and S3 subsites between the two enzymes, though their substrate specificities are apparently indistinguishable.
Patent
An anti-amnestic agent
TL;DR: An anti-amnestic agent which comprises as an active ingredient thereof at least one prolinal derivative of the general formula I is defined in this article, wherein A is a protective group for amino group in the field of amino acid chemistry and X is a residue of an amino acid, in a pharmacologically active amount together with an excipient.