K
Kurt G. Beam
Researcher at University of Colorado Denver
Publications - 127
Citations - 9217
Kurt G. Beam is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Ryanodine receptor & Voltage-dependent calcium channel. The author has an hindex of 52, co-authored 123 publications receiving 8881 citations. Previous affiliations of Kurt G. Beam include Kyoto University & Anschutz Medical Campus.
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Journal ArticleDOI
Restoration of excitation—contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA
TL;DR: Microinjection of an expression plasmid that carries complementary DNA encoding the receptor for dihydropyridine calcium channel blockers of skeletal muscle restores both excitation-contraction coupling and slow calcium current in cultured skeletal muscle cells from mice with muscular dysgenesis.
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Regions of the skeletal muscle dihydropyridine receptor critical for excitation-contraction coupling.
TL;DR: The results obtained indicate that the putative cytoplasmic region between repeats II and III of the skeletal muscle DHP receptor3 is an important determinant of skeletal-type EC coupling.
Journal ArticleDOI
Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor.
Junichi Nakai,Junichi Nakai,Robert T. Dirksen,Hanh T. Nguyen,Isaac N. Pessah,Kurt G. Beam,Paul D. Allen +6 more
TL;DR: The results support the possibility of a retrograde signal by which RyR-1 enhances the function of DHPRs as Ca2+ channels, and measurements of charge movement indicate that the density ofDHPRs is similar in dyspedic and Ry R-1-expressing myotubes.
Journal ArticleDOI
Intramembrane charge movement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor cDNAs.
TL;DR: The results indicate that charge movement is deficient in dysgenic myotubes but is fully restored following injection of an expression plasmid carrying the rabbit skeletal muscle DHP receptor complementary DNA, strongly supporting the hypothesis that the DHP receptors is the voltage sensor for EC coupling in skeletal muscle.
Journal ArticleDOI
Cardiac-type excitation-contraction coupling in dysgenic skeletal muscle injected with cardiac dihydropyridine receptor cDNA
TL;DR: The properties of the L-type channels pro-duced were compared and it was shown that expression of a cardiac calcium channel in skeletal muscle cells results in ?