K
Kyle W. Jackson
Researcher at Johns Hopkins University
Publications - 10
Citations - 4530
Kyle W. Jackson is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Progenitor cell & Adult stem cell. The author has an hindex of 6, co-authored 8 publications receiving 4333 citations. Previous affiliations of Kyle W. Jackson include University of Michigan.
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Journal ArticleDOI
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
Gabriela Dontu,Wissam M. Abdallah,Jessica M. Foley,Kyle W. Jackson,Michael F. Clarke,Mari J. Kawamura,Max S. Wicha +6 more
TL;DR: It is demonstrated that nonadherent mammospheres are enriched in early progenitor/stem cells and able to differentiate along all three mammary epithelial lineages and to clonally generate complex functional structures in reconstituted 3D culture systems.
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Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells.
Suling Liu,Gabriela Dontu,Ilia D. Mantle,Shivani H. Patel,Nam Shik Ahn,Kyle W. Jackson,Prerna Suri,Max S. Wicha +7 more
TL;DR: A cancer stem cell model in which the hedgehog pathway and Bmi-1 play important roles in regulating self-renewal of normal and tumorigenic human mammary stem cells is supported.
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Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
Gabriela Dontu,Kyle W. Jackson,Erin McNicholas,Mari J. Kawamura,Wissam M. Abdallah,Max S. Wicha +5 more
TL;DR: It is suggested that Notch signaling plays a critical role in normal human mammary development by acting on both stem cells and progenitor cells, affecting self-renewal and lineage-specific differentiation.
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Size-based detection of sarcoma circulating tumor cells and cell clusters.
Masanori Hayashi,Peixuan Zhu,Gregory McCarty,Christian F. Meyer,Christine A. Pratilas,Adam S. Levin,Carol D. Morris,Catherine M. Albert,Catherine M. Albert,Kyle W. Jackson,Cha Mei Tang,David M. Loeb +11 more
TL;DR: This work demonstrates that the CellSieve™ microfiltration system can be used to study the biology of CTC in both mouse models and human sarcoma patients, with the potential for application to the monitoring of disease response and prediction of metastatic relapse.
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An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis.
TL;DR: An orthotopic implantation/amputation model in which patient-derived sarcoma xenografts are surgically implanted into mouse hindlimbs, allowed to grow, then subsequently amputated and the animals observed for development of metastases is developed.