K
Kyoung S. Kim
Researcher at Bristol-Myers Squibb
Publications - 51
Citations - 2426
Kyoung S. Kim is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 25, co-authored 51 publications receiving 2330 citations.
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Journal ArticleDOI
Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily
Gretchen M. Schroeder,Yongmi An,Zhen-Wei Cai,Xiao-Tao Chen,Cheryl M. Clark,Cornelius Lyndon A M,Jun Dai,Johnni Gullo-Brown,Ashok Kumar Gupta,Benjamin J. Henley,John T. Hunt,Robert Jeyaseelan,Amrita Kamath,Kyoung S. Kim,Jonathan Lippy,Louis J. Lombardo,Veeraswamy Manne,Simone Oppenheimer,John S. Sack,Robert J. Schmidt,Guoxiang Shen,Kevin Stefanski,John S. Tokarski,George L. Trainor,Barri Wautlet,Donna D. Wei,David K. Williams,Yingru Zhang,Yueping Zhang,Joseph Fargnoli,Robert M. Borzilleri +30 more
TL;DR: Analogue 10 demonstrated complete tumor stasis in a Met-dependent GTL-16 human gastric carcinoma xenograft model following oral administration and has been advanced into phase I clinical trials.
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N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.
Raj N. Misra,Hai-Yun Xiao,Kyoung S. Kim,Songfeng Lu,Wen-Ching Han,Stephanie Barbosa,John T. Hunt,Rawlins David B,Weifang Shan,Syed Z. Ahmed,Ligang Qian,Bang-Chi Chen,Rulin Zhao,Mark S. Bednarz,Kristen A. Kellar,Janet G. Mulheron,Roberta Batorsky,Urvashi V. Roongta,Amrita Kamath,Punit Marathe,Sunanda A. Ranadive,John S. Sack,John S. Tokarski,Nikola P. Pavletich,Francis Y. Lee,Kevin R. Webster,S. David Kimball +26 more
TL;DR: Ncyl-2-aminothiazoles with nonaromatic acyl side chains containing a basic amine were found to be potent, selective inhibitors of CDK2/cycE which exhibit antitumor activity in mice.
Journal ArticleDOI
Improved method for the preparation of guanidines
Kyoung S. Kim,Ligang Qian +1 more
TL;DR: In this paper, the use of N,N′-di-(tert-butoxycarbonyl)thiourea 1 in the presence of mercuric chloride provides a very efficient method for the bis-Boc protected guanidine formation of the amino compounds which are highly deactivated either sterically or electronically.
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Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities
Kyoung S. Kim,S. David Kimball,Raj N. Misra,Rawlins David B,John T. Hunt,Hai Yun Xiao,Songfeng Lu,Ligang Qian,Wen Ching Han,Weifang Shan,Toomas Mitt,Zhen Wei Cai,Michael A. Poss,Hong Zhu,John S. Sack,John S. Tokarski,Chieh Ying Chang,Nikola P. Pavletich,Amrita Kamath,William G. Humphreys,Punit Marathe,Isia Bursuker,Kristen A. Kellar,Urvashi V. Roongta,Roberta Batorsky,Janet G. Mulheron,David Bol,Craig R. Fairchild,Francis Y. Lee,Kevin R. Webster +29 more
TL;DR: Optimization led to compounds such as water soluble 45, which possesses a favorable pharmacokinetic profile in mice and demonstrates significant antitumor activity in vivo in several murine and human models, including an engineered murine mammary tumor that overexpresses cyclin E, the coactivator of CDK2.
Journal ArticleDOI
Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.
Kyoung S. Kim,Liping Zhang,Robert J. Schmidt,Zhen-Wei Cai,Donna D. Wei,David K. Williams,Louis J. Lombardo,George L. Trainor,Dianlin Xie,Yaquan Zhang,Yongmi An,John S. Sack,John S. Tokarski,Celia D’Arienzo,Amrita Kamath,Punit Marathe,Yueping Zhang,Jonathan Lippy,Robert Jeyaseelan,Barri Wautlet,Benjamin J. Henley,Johnni Gullo-Brown,Veeraswamy Manne,John T. Hunt,Joseph Fargnoli,Robert M. Borzilleri +25 more
TL;DR: Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor that possesses a favorable pharmacokinetic profile in mice and demonstrates significant in vivo antitumor activity in the GTL-16 human gastric carcinoma xenograft model.