Showing papers by "L. Ashley Cowart published in 2020"

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Journal Article•DOI•

Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease

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Andrea K. Anderson¹, Andrea K. Anderson², Johana M. Lambert¹, Johana M. Lambert², David J. Montefusco¹, Bao Ngan Tran¹, Patrick Roddy², William L. Holland³, L. Ashley Cowart⁴, L. Ashley Cowart¹ - Show less +6 more•Institutions (4)

Virginia Commonwealth University¹, Medical University of South Carolina², University of Utah³, Veterans Health Administration⁴

20 Jul 2020-Journal of Lipid Research

TL;DR: Interestingly, hepatocyte triacylglycerol accumulation and expression of pro-inflammatory cytokines and collagen 1a1 were exacerbated in SK1fatKO mice on a HFD, implicating a specific role for adipocyte SPHK1 in adipocyte function and inter-organ cross-talk that maintains overall metabolic homeostasis in obesity.

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13 citations