Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone

Transition metal complexes with binucleating ligands

Antitumour copper(II) salicylaldehyde benzoylhydrazone (H2sb) complexes: physicochemical properties and the single-crystal X-ray structures of [{Cu(H2sb)(CCl3CO2)2}2] and [{Cu(Hsb) (ClO4) (C2H5OH)}2] and the related salicylaldehyde acetylhydrazone (H2sa) complex, [Cu(Hsa)Cl(H2O)]·h2O

A new series of geometrically different complexes containing ferrocenyl hydrazone ligands were synthesised by reacting suitable precursor complex [MCl2(PPh3)2] with the ligands HL1 or HL2 (where M = Cu(II) or Ni(II); HL1 = [Cp2Fe(CHN–NH –CO– C6H5)] (1) and HL2 = [Cp2Fe(CHN–NH–CO–C5H4N)]) (2). The new complexes of the composition [Cu(L1)(PPh3)2], (3) [Cu(L2)(PPh3)2] (4), [Ni(L1)2] (5) and [Ni(L2)2] (6) were characterised by various spectral studies. Among them, complexes 3 and 5 characterised by single crystal X-ray diffraction showed a distorted tetrahedral structure for the former with 1 : 1 metal–ligand stoichiometry, but a distorted square planar geometry with 1 : 2 metal–ligand stoichiometry in the case of the latter. Systematic biological investigations like DNA binding, DNA cleavage, protein binding, free radical scavenging and cytotoxicity activities were carried out using all the synthesised compounds and the results obtained were explained on the basis of structure–activity relationships. The binding constant (Kb) values of the synthesised compounds are found to be in the order of magnitude 103–105 M−1 and also they exhibit significant cleavage of supercoiled (SC) pUC19 DNA in the presence of H2O2 as co-oxidant. The conformational changes of bovine serum albumin (BSA) upon binding with the above complexes were also studied. In addition, concentration dependent free radical scavenging potential of all the synthesised compounds (1–6) was also carried out under in vitro conditions. Assays on the cytotoxicity of the above complexes against HeLa and A431 tumor cells and NIH 3T3 normal cells were also carried out.

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Copper(I) and nickel(II) complexes with 1 : 1 vs. 1 : 2 coordination of ferrocenyl hydrazone ligands: Do the geometry and composition of complexes affect DNA binding/cleavage, protein binding, antioxidant and cytotoxic activities?

Bis-acyl-/aroyl-hydrazones as multidentate ligands

Coordination compounds of hydrazine derivatices with transition metals—XIX

Coordination compounds of hydrazine derivatives with transition metals. X. Cobalt(II) aroylhydrazone complexes

Coordination compounds of hydrazine derivatives with transition metals. VIII. Copper(II) complexes with salicylaldehyde and acetylacetone aroyl-hydrazones.

Coordination compounds of hydrazine derivatives with transition metals—XII Nickel(II) and copper(II) chelates of bis(n-salicylidene)dicarboxylic acid dihydrazides

The reaction of bis(N-salicylidene)dicarboxylic acid dihydrazides (H4Lig) with cobalt(II) salts was investigated. Chelates of the types Co(H3Lig)X ·nH2O, Co2(H2Lig)X2, Co3(H3Lig)2X4, Co(H2Lig) ·nH2O and Co(H3Lig)2 ·nH2O (X=Cl, Br, I or SCN) were isolated and characterized by their infrared and electronic spectra as well as their magnetic properties.

L. El Sayed

Papers

Coordination compounds of hydrazine derivatices with transition metals—XIX

Coordination compounds of hydrazine derivatives with transition metals. X. Cobalt(II) aroylhydrazone complexes

Coordination compounds of hydrazine derivatives with transition metals. VIII. Copper(II) complexes with salicylaldehyde and acetylacetone aroyl-hydrazones.

Coordination compounds of hydrazine derivatives with transition metals—XII Nickel(II) and copper(II) chelates of bis(n-salicylidene)dicarboxylic acid dihydrazides

Coordination compounds of hydrazine derivatives with transition metals, XXIII cobalt(II) chelates of bis(N-salicylidene)dicarboxylic acid dihydrazides