Crystal properties of N -alkyl-substituted glycolurils as the precursors of chiral drugs

A new simple approach to the preparation of imidazo[4,5-e]-1,2,4-triazine derivatives

New condensation methods in the synthesis of bicyclic bisureas

Target synthesis of bioactive thioglycolurils, based on QSAR predictions

Effect of temperature on volumetric behavior of glycine in aqueous mebicar (N-tetramethylglycoluril) at p ~ 0.1 MPa

A general preparative method has been developed for the alkylation of BBU with various structures using alkyl iodides and liquid ammonia by the action of sodium amide in the presence of alkali halide salts

The chemistry of bicyclic bisureas: 2. N-alkylation of bicyclic bisureas

The Surface Molecular Potential Method for Calculating the Structure–Activity Relationship for Psychotropic Compounds

1.

Unsubstituted and tetra-N-methyl-substituted bicyclic bisureas (BBU) of the octane and nonane series on reaction with triethyloxonium fluoroborate form O-alkylation products at both carbonyl groups, namely the difluoroborates of 3,7-diethoxy-2,6-diaza-4,8-diazoniabicyclo[3.3.0]octane-3,7-dienes and 3,7-diethoxy-2,6-diaza-4,8-diazoniabicyclo[3.3.1]nonane-3,7-dienes.




2.

On hydroylsis of the O-alkylation products of tetra-N-methyl-substituted BBU, the reaction resulting in the fission of one of the rings predominates.

The chemistry of bicyclic bisureas. 3. The synthesis and hydrolytic stability of the difluoroborate salts of 3,7-diethoxy-2,6-diaza-4,8-diazoniabicyclo[3.3.0]octane-3,7-dienes and 3,7-diethoxy-2,6-diaza-4,8-diazoniabicyclo[3.3.1]non-ane-3,7-dienes

Infrared spectra and structure of 1,1-dinitroalkane salts

1.

When LiAlH4, is allowed to react with unsubstituted, di-, and tetra-N-alkylated bicyclic bisureas (BBU) of the octane and nonane series, reduction takes place only in the case of tetra-N-alkyl BBU, reduction of one or both carbonyl groups taking place according to the structure of the BBU.




2.

Reaction of non-N-alkylated O-alkyl BBU with nucleophilic reagents results in deprotonation with the formation of bicyclic isoureas.

L. I. Suvorova

Papers

The chemistry of bicyclic bisureas: 2. N-alkylation of bicyclic bisureas

The Surface Molecular Potential Method for Calculating the Structure–Activity Relationship for Psychotropic Compounds

The chemistry of bicyclic bisureas. 3. The synthesis and hydrolytic stability of the difluoroborate salts of 3,7-diethoxy-2,6-diaza-4,8-diazoniabicyclo[3.3.0]octane-3,7-dienes and 3,7-diethoxy-2,6-diaza-4,8-diazoniabicyclo[3.3.1]non-ane-3,7-dienes

Infrared spectra and structure of 1,1-dinitroalkane salts

The chemistry of bicyclic bisureas. 4. Reduction of bicyclic bisureas and their O-alkyl derivatives