L. M. Knobeloch

TL;DR: The RET reaction was chosen over other methods because responses are easily quantifiable and the energy-coupled RET reaction is competent in reconstituted freeze-dried submitochondrial particles, thus, SMP - a stable biological preparation- can be distributed to other laboratories.

TL;DR: In this paper, a new spectrophotometric bioassay procedure was developed for evaluating chemical toxicity, using electron transport particles isolated from bovine heart mitochondria, based on the ability of many toxic chemicals to interfere with the integrated function of electron transport enzymes.

TL;DR: The mitochondrial tests are good indicators of the relative toxicity of many xenobiotics to cells and fish and the ability of these procedures to predict in vivo tissue concentrations associated with clinical illness in man is studied.

TL;DR: A new, rapid, and reliable bioassay for monitoring the acute toxicity of aquatic samples has been developed based on metabolic changes in preparations made from isolated animal mitochondria which affect theratio of reduced to oxidized nicotinamide adenine dinucleotide (NADH/NAD) as measured in a spectrophotometer.