The invention provides methods for treating and/or preventing and/or slowing the onset and/or development of ALS using hydrogenated pyrido(4,3-b)indoles, such as dimebon.

Hydrogenated pyrido (4,3-b) indoles for treating amyotrophic lateral sclerosis (als)

The scanning process of a television camera is modified so that scanning is inhibited for N successive scan periods and is enabled during the next scan period, in a repeating cycle of (N+1) periods duration. The signal output generated during the N inhibited scan periods is zero but, during the enabled scan period, is (N+1) times greater than the corresponding signal which would be generated by conventional scanning action.

Apparatus and method for generating optimizing pictures under low light conditions

An apparatus for correcting electron-beam alignment comprises monitoring means for monitoring the shading of the electro-optical tube image, adjustment means for decreasing the tube target bias voltage so that a measurable shading is introduced in the tube image, as monitored by the monitoring means, and control means for varying the tube alignment until the monitoring means monitors a minimum average shading, which condition is considered to indicate optimum beam align­ ment. In an apparatus for setting the beam current the beam current is switched off during fields scans so that the target charge excedes that produced by the operationel peak light level. The beam current is adjusted so as to discharge this increased target charge. Preferably, the camera tube is sub­ jected to the operational peak light level and the beam current is switched off for two consecutive fields scans. This ensures that the target charge is at least twice that produced by the operational peak light level and that both odd and even fields are alternately discharged.

Electro-optical tube alignment and beam current adjustment

A process and apparatus for the remote pickup and reproduction of image of static or dynamic objects in which dark regions of a target provide outputs below a threshold value which are normalized or averaged through a divider during intervals of line scan interruption brought about by the detection of a below threshold level. The system, therefore, allows integration during the interval and by averaging and integrating values permits discernment of features which might otherwise be obscured by a leveling effect in dark regions.

Process and circuit arrangement for the remote pick up and reproduction of images of static or moving objects

This image pickup apparatus is capable of picking up very low level images, such as a star or a comet in a night sky, and is capable of obtaining a video signal having a desired S/N ratio without using a conventional noise reducer. The apparatus comprises a television camera including an image pickup tube, a field memory for storing a video signal delivered from the television camera, and a write-inhibiting control circuit, wherein a period of beam scanning for generating the video signal in the image pickup tube is extended to n-times the standard field period for increasing the sensitivity of the image pickup tube. Writing to the field memory is inhibited in other periods except for the beam scanning period, while a normal television signal is continuously obtained from the field memory. A key signal corresponding to dark portions of the image that are not to be enhanced may be generated and stored in an area memory, and then read out from the area memory during every standard field period. An imaging control circuit responsive to the imaging control signal and the key signal then controls the image pickup device, such that it extracts a videeo signal from the whole of an imaging area during the period of one field designated by the imaging control signal, and extracts a video signal from a partial area apecified by the key signal during other field periods.

Highly sensitive image pickup apparatus

A circuit arrangement for increasing the signal-to-noise ratio of the picture output signal of a television camera tube by alternately blanking the scanning of the image applied to the tube during at least one line scanning period and scanning, during a following line scanning period, a band which covers an adjacent image portion associated with the at least one blanked scanning line.

L Niemyer

Papers

Apparatus for increasing signal to noise ratio in television low light level scenes