L
L. P. Svedersky
Researcher at Genentech
Publications - 8
Citations - 1808
L. P. Svedersky is an academic researcher from Genentech. The author has contributed to research in topics: Lymphotoxin & Interferon gamma. The author has an hindex of 6, co-authored 8 publications receiving 1798 citations.
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Journal Article
Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.
M R Shalaby,Bharat B. Aggarwal,E Rinderknecht,L. P. Svedersky,B. S. Finkle,Michael A. Palladino +5 more
TL;DR: Although lipopolysaccharide (LPS) is a potent stimulator of PMN function, polymyxin B can block LPS-induced but not lymphokine-induced activation, demonstrating new activities for both TNF-alpha and T NF-beta in augmenting the phagocytic and cytotoxic activities of PMn.
Journal ArticleDOI
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.
Patrick W. Gray,Bharat B. Aggarwal,Charles V. Benton,Timothy S. Bringman,William J. Henzel,Julie A. Jarrett,David W. Leung,Barbara Moffat,Peter Ng,L. P. Svedersky,Michael A. Palladino,Glenn Evan Nedwin +11 more
TL;DR: Purified recombinant lymphotoxin shows cytotoxic activity on murine and human tumour cell lines in vitro and causes necrosis of certain murine sarcomas in vivo.
Journal Article
Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes.
P M Peters,J R Ortaldo,M R Shalaby,L. P. Svedersky,Glenn Evan Nedwin,T S Bringman,Philip E. Hass,Bharat B. Aggarwal,R B Herberman,David V. Goeddel +9 more
TL;DR: It is suggested that NK function can be attributed to a combination of factors rather than to a single factor alone, and that at least two major phenomena are involved in LGL function: the rapid cytotoxic events which lead to the cell lysis measured in classical in vitro NK assays such as against K562; and the release of factors such as TNF-alpha with cytotoxicity/cytostatic activities which would inhibit the growth of invading tumor cells in vivo.
Journal Article
Interferon-gamma enhances induction of lymphotoxin in recombinant interleukin 2-stimulated peripheral blood mononuclear cells.
TL;DR: Results suggest that rIL 2, in addition to being a T cell growth factor, may exhibit other activities through induction of LT and IFN-gamma.
Journal ArticleDOI
Induction and augmentation of mitogen‐induced immune interferon production in human peripheral blood lymphocytes by Nα‐desacetylthymosin αl
TL;DR: Treatment of human peripheral blood lymphocytes with cloned Nα‐desacetylthymosin α1 induced interferon production and results indicate that thymic factors may also participate in the regulation of IFN‐γ production.