Excerpt CONTENTS Part One: I. Introduction. II. Physiology of cholesterol metabolism. Part Two: Presentation of cases. I. Primary essential xanthomatosis. A. Primary essential xanthomatosis of the ...

An article contributed to an anniversary volume in honor of doctor joseph hersey pratt: the different clinical groups of xanthomatous diseases; a clinical physiological study of 22 cases

An article contributed to an anniversary volume in honor of doctor joseph hersey pratt

Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans

Pathologic Considerations Pathogenesis in Relation to Hyperlipoidemia and the Reticulo-Endothelial System CONTENTS Introduction. Report of Cases. Resume of Cases Showing Christian's Syndrome. Christian's Syndrome and Xanthomatosis. Historical Consideration of Xanthoma in Relation to Christian's Syndrome. Constituion General Account General comment of the Symptomologic considerations Clinical Picture Clinical and symptomologic considerations concerning syndrome Microscopic changes Microscopic and clinical changes Microscopic changes concerning the syndrome Study of microscopic changes—conclusions Pathogenic theories Hypercholesterinemia Hyperlipoidemia—clinical consideration Hypercholesterinemia and animal experimentation The reticulo-endothelial system and xanthomatosis General Comment in Relation to the Syndrome. Conclusions regarding pathogenesis. Conditions that should be included as manifestations of a general disturbance of lipoid metabolism. The nature of the nodular lesions. Clinical features in general. Summary and Conclusions. INTRODUCTION Xanthoma was first described as a rare disease of the skin. It is still classed as a dermatologic condition, although for a long time it has, in all its many

Xanthomatosis and the reticuloendothelial system: correlation of an unidentified group of cases described as defects in membranous bones, exophthalmos and diabetes insipidus (christian's syndrome)

Diagnostic pathologists as a group might be regarded as a conservative group of physicians. Although changes and new procedures have been and are being introduced all the time, the lag period between introduction of new diagnostic procedures in experimental studies on animals and their application to human pathology is often long. Accordingly, the present review will include observations made on experimental animals which seem to be applicable to human diagnostic pathology, in addition to observations actually made on human material in which polarized light microscopy was of direct help in establishing the diagnosis. Following this line of reasoning the review will also include

L. Pick

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Zur Struktur und Genese der symptomatischen Xanthome1)