Showing papers by "L. Stefan Lohmander published in 2000"
TL;DR: The genetics of osteoarthritis are clarified, those at risk for progression and severe disease are identified, and molecular processes critical for joint survival and failure are identified.
Abstract: Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be gained by more effective 'low-tech-low-cost' treatment. However, many patients have rapidly progressive disease, multiple joint involvement, and severe disease. We need to clarify the genetics of osteoarthritis, identify those at risk for progression and severe disease, and identify molecular processes critical for joint survival and failure. Will saving the cartilage improve patient pain and function? Effective outcome measures are needed to accelerate testing of new treatments. Further improvement is needed in joint implant technology to decrease costs, wear and loosening.
60 citations
TL;DR: Histologica changes of the articular cartilage, consistent with early‐stage osteoarthritis, were evident at stage 3 and were more advanced at stage 4, and levels of matrix metalloproteinase‐3 and molar ratios of matrix meetallop proteinase‐2/tissue inhibitor of metalloplatformases‐1 were higher in early stage disease than in later stage disease.
25 citations