L
Lars Christian Rump
Researcher at University of Düsseldorf
Publications - 248
Citations - 12878
Lars Christian Rump is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Blood pressure & Kidney. The author has an hindex of 51, co-authored 229 publications receiving 11322 citations. Previous affiliations of Lars Christian Rump include Ruhr University Bochum.
Papers
More filters
Journal ArticleDOI
Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis
Eva Königshausen,Ulf M. Zierhut,Martin Ruetze,Sebastian A. Potthoff,Johannes Stegbauer,Magdalena Woznowski,Ivo Quack,Lars Christian Rump,Lorenz Sellin +8 more
TL;DR: It is concluded that Ang II weakens the structural integrity of the slit diaphragm by increased nephrin endocytosis and decreased nephin binding to nck2, which leads to increased glomerular permeability.
Journal ArticleDOI
Modulation of gene expression by moxonidine in rats with chronic renal failure
Oliver Vonend,T. Apel,Kerstin Amann,Lorenz Sellin,Johannes Stegbauer,Eberhard Ritz,Lars Christian Rump +6 more
TL;DR: Several genes showing altered expression levels after subtotal nephrectomy were identified in remnant kidneys and might act as candidates to promote disease progression.
Journal ArticleDOI
Angiotensin-(1-7)-induced Mas receptor activation attenuates atherosclerosis through a nitric oxide-dependent mechanism in apolipoproteinE-KO mice
Guang Yang,Geoffrey Istas,Sascha Höges,Mina Yakoub,Ulrike B. Hendgen-Cotta,Tienush Rassaf,Ana Rodriguez-Mateos,Lydia Hering,Maria Grandoch,Evanthia Mergia,Lars Christian Rump,Johannes Stegbauer +11 more
TL;DR: It is proved that Ang-(1-7) mediates its protective vascular effects through Mas receptor activation and is essential for improving vascular function and prevents atherosclerosis in apoE-KO mice.
Journal ArticleDOI
α2A-Adrenoceptors Regulate Sympathetic Transmitter Release in Mice Kidneys
TL;DR: A rodent model was used to investigate whether the α2A‐adrenoceptor (α2A) represents the presynaptic autoinhibitory receptor regulating sympathetic transmitter release in the kidney and the potential role of α2 a heteroceptor regulating adenosine triphosphate (ATP) release was tested.
Journal ArticleDOI
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
Johannes Stegbauer,Sean E. Thatcher,Guang Yang,Katharina Bottermann,Lars Christian Rump,Alan Daugherty,Lisa A. Cassis +6 more
TL;DR: MasR deficiency augmented AngII-induced atherosclerosis and AAA rupture through mechanisms involving increased oxidative stress, inflammation, and apoptosis, suggesting that MasR activation may provide therapeutic efficacy against vascular diseases.