Laura Facci

TL;DR: It is reported that mast cells express both the gene and a functional CB2 receptor protein with negative regulatory effects on mast cell activation, and palmitoylethanolamide and its derivatives may provide antiinflammatory therapeutic strategies specifically targeted to mast cells.

TL;DR: The results suggest that non-CB1 cannabinoid receptors control, upon agonist binding, the downstream consequences of an excitotoxic stimulus and activation of such receptors may serve to downmodulate deleterious cellular processes following pathological events or noxious stimuli in both the nervous and immune systems.

TL;DR: This review will describe the current state of knowledge concerning the biology of neuroinflammation, emphasizing mast cell-glia and glia- glia interactions, then conclude with a consideration of how a cell's endogenous mechanisms might be leveraged to provide a therapeutic strategy to target neuro inflammation.

TL;DR: An overview of recent progress relating to the pathobiology of neuroinflammation, the role of microglia, neuroimmune interactions involving mast cells, in particular, and the possibility that mast cell‐microglia crosstalk may contribute to the exacerbation of acute symptoms of chronic neurodegenerative disease and accelerate disease progression, are provided.

TL;DR: An overview of recent progress relating to the pathobiology of neuroinflammation, the role of microglia, neuroimmune interactions involving mast cells and the possibility that mast cell–microglia cross‐talk contributes to the exacerbation of acute symptoms of chronic neurodegenerative disease and accelerates disease progression is provided.