L
Laura Jiménez-Pelayo
Researcher at Complutense University of Madrid
Publications - 13
Citations - 215
Laura Jiménez-Pelayo is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Neospora caninum & Immune system. The author has an hindex of 8, co-authored 13 publications receiving 147 citations.
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Journal ArticleDOI
Systemic and local immune responses in sheep after Neospora caninum experimental infection at early, mid and late gestation
David Arranz-Solís,Julio Benavides,Javier Regidor-Cerrillo,Pilar Horcajo,Pablo Castaño,María del Carmen Ferreras,Laura Jiménez-Pelayo,Esther Collantes-Fernández,Ignacio Ferre,Andrew Hemphill,Valentín Pérez Pérez,Luis Miguel Ortega-Mora +11 more
TL;DR: The pivotal role of systemic and local immune responses at different times of gestation during N. caninum infection in sheep is confirmed.
Journal ArticleDOI
Transcriptome modulation of bovine trophoblast cells in vitro by Neospora caninum.
Pilar Horcajo,Laura Jiménez-Pelayo,Marta García-Sánchez,Javier Regidor-Cerrillo,Esther Collantes-Fernández,Daniel Rozas,Nina Hambruch,Christiane Pfarrer,Luis Miguel Ortega-Mora +8 more
TL;DR: A global view is provided of Neospora caninum interactions with bovine trophoblast cells and of the intra-specific differences between two Neosporinum isolates with biological differences.
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Differential Responses of Bovine Monocyte-Derived Macrophages to Infection by Neospora caninum Isolates of High and Low Virulence
Marta García-Sánchez,Laura Jiménez-Pelayo,Pilar Horcajo,Javier Regidor-Cerrillo,Einar B. Ólafsson,Amol K. Bhandage,Antonio Barragan,Dirk Werling,Luis Miguel Ortega-Mora,Esther Collantes-Fernández +9 more
TL;DR: This work characterizes for the first time N. caninum replication in bovine monocyte-derived MØs and details isolate-dependent differences in host cell responses to the parasite.
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Differential susceptibility of bovine caruncular and trophoblast cell lines to infection with high and low virulence isolates of Neospora caninum.
Laura Jiménez-Pelayo,Marta García-Sánchez,Javier Regidor-Cerrillo,Pilar Horcajo,Esther Collantes-Fernández,Mercedes Gómez-Bautista,Nina Hambruch,Christiane Pfarrer,Luis Miguel Ortega-Mora +8 more
TL;DR: A highly similar behavior of high- and low-virulence isolates in their interactions with maternal caruncular cells is indicated and an important role of foetal trophoblasts in the pathogenesis of N. caninum infection is suggested.
Journal ArticleDOI
Immune response profile of caruncular and trophoblast cell lines infected by high- (Nc-Spain7) and low-virulence (Nc-Spain1H) isolates of Neospora caninum
Laura Jiménez-Pelayo,Marta García-Sánchez,Javier Regidor-Cerrillo,Pilar Horcajo,Esther Collantes-Fernández,Mercedes Gómez-Bautista,Nina Hambruch,Christiane Pfarrer,Luis Miguel Ortega-Mora +8 more
TL;DR: Neospora caninum infection is shown to favor a pro-inflammatory response in placental target cells in vitro, and significant immunomodulation differences were observed between high- and low-virulence isolates, which would partially explain the differences in virulence.