L
Laura Martín-Díaz
Publications - 2
Citations - 196
Laura Martín-Díaz is an academic researcher. The author has contributed to research in topics: Tumor progression & Stromal cell. The author has an hindex of 2, co-authored 2 publications receiving 120 citations.
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Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors
Magdolna Djurec,Osvaldo Graña,Albert Lee,Kevin Troulé,Elisa Espinet,Lavinia Cabras,Carolina Navas,María Teresa Blasco,Laura Martín-Díaz,Miranda Burdiel,Jing Li,Zhaoqi Liu,Mireia Vallespinós,Francisco Sanchez-Bueno,Martin R. Sprick,Andreas Trumpp,Bruno Sainz,Fatima Al-Shahrour,Raul Rabadan,Carmen Guerra,Mariano Barbacid +20 more
TL;DR: Findings support the concept that selective inhibition of SAA1 in CAFs may provide potential therapeutic benefit to PDAC patients and provide genetic evidence that one of these genes, Saa3, plays a key role on the protumorigenic properties of the stroma, opening the door to the design of future therapeutic strategies.
Journal ArticleDOI
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF
María Teresa Blasco,Carolina Navas,Guillermo Martín-Serrano,Osvaldo Graña-Castro,Carmen G. Lechuga,Laura Martín-Díaz,Magdolna Djurec,Jing Li,Lucia Morales-Cacho,Laura Esteban-Burgos,Javier Perales-Patón,Emilie Bousquet-Mur,Eva Castellano,Harrys K.C. Jacob,Lavinia Cabras,Monica Musteanu,Matthias Drosten,Sagrario Ortega,Francisca Mulero,Bruno Sainz,Nelson Dusetti,Juan L. Iovanna,Francisco Sanchez-Bueno,Manuel Hidalgo,Hossein Khiabanian,Raul Rabadan,Fatima Al-Shahrour,Carmen Guerra,Mariano Barbacid +28 more
TL;DR: Combined ablation of EGFR and c-RAF expression results in complete regression of a significant percentage of PDAC tumors driven by Kras/Trp53 mutations in genetically engineered mice, opening the door to the development of targeted therapies for PDAC patients.