L
Lauren M. DeSalle
Researcher at Wistar Institute
Publications - 2
Citations - 134
Lauren M. DeSalle is an academic researcher from Wistar Institute. The author has contributed to research in topics: Leucine zipper & Gene expression profiling. The author has an hindex of 2, co-authored 2 publications receiving 127 citations.
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Journal ArticleDOI
Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein.
Xiao-yong Zhang,Lauren M. DeSalle,Jagruti H. Patel,Anthony J. Capobianco,Duonan Yu,Andrei Thomas-Tikhonenko,Steven B. McMahon +6 more
TL;DR: The data reported here demonstrate that endogenous c-MYC binds to the genomic MTA1 locus and recruits transcriptional coactivators, and short hairpin RNA (shRNA)-mediated knockdown of MTA1 blocks the ability of c- MYC to transform mammalian cells.
Journal ArticleDOI
Identification of novel targets of MYC whose transcription requires the essential MbII domain
TL;DR: The identity of these previously uncharacterized MYCtargets is reported and their potential roles in MYC function are discussed and the historical and contemporary evidence linking MbII to transcriptionalactivation is attempted.