L
Lei Han
Researcher at Centers for Disease Control and Prevention
Publications - 79
Citations - 986
Lei Han is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Medicine & Pulmonary fibrosis. The author has an hindex of 14, co-authored 55 publications receiving 599 citations. Previous affiliations of Lei Han include Nanjing Medical University & Public Health Research Institute.
Papers
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Journal ArticleDOI
miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF.
Qiuyun Wu,Lei Han,Lei Han,Weiwen Yan,Xiaoming Ji,Ruhui Han,Jingjin Yang,Jiali Yuan,Chunhui Ni +8 more
TL;DR: The data indicate that the CHRF-miR-489-MyD88 Smad3 signaling axis exerts key functions in silica-induced pulmonary fibrosis and may represent a therapeutic target for silicosis.
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The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis
Xiaoming Ji,Baiqun Wu,Jingjing Fan,Ruhui Han,Chen Luo,Ting Wang,Jingjin Yang,Lei Han,Lei Han,Baoli Zhu,Dong Wei,Jingyu Chen,Chunhui Ni +12 more
TL;DR: Results indicate that miR-486-5p may inhibit fibrosis, as determined by luciferase assays and Western blotting and to test the potential therapeutic significance of this miRNA, it is shown that it is overexpressed in animal models.
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The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis.
TL;DR: Results indicated that the interaction between miR-7 and circRNA CDR1as may exert important functions and provide potential therapeutic targets in lung fibrotic diseases.
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MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2.
Ruhui Han,Xiaoming Ji,Rong Rong,Yan Li,Wenxi Yao,Jiali Yuan,Qiuyun Wu,Jingjin Yang,Weiwen Yan,Lei Han,Lei Han,Baoli Zhu,Chunhui Ni +12 more
TL;DR: The results suggest that miR-449a is an important regulator of autophagy, as well as a novel endogenous suppressor of pulmonary fibrosis.
Journal ArticleDOI
Effects of glyphosate exposure on sperm concentration in rodents: A systematic review and meta-analysis
Wenyan Cai,Ying Ji,Xianping Song,Haoran Guo,Lei Han,Feng Zhang,Xin Liu,Hengdong Zhang,Baoli Zhu,Ming Xu +9 more
TL;DR: The results of meta-analysis support the hypothesis that glyphosate exposure decreased sperm concentration in rodents and conclude that glyphosate is toxic to male rodent's reproductive system.