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Lei Kuang
Researcher at Third Military Medical University
Publications - 14
Citations - 146
Lei Kuang is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Sepsis & Medicine. The author has an hindex of 4, co-authored 12 publications receiving 47 citations.
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Journal ArticleDOI
Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways.
Chenyang Duan,Lei Kuang,Xiang Xinming,Jie Zhang,Yu Zhu,Yue Wu,Qing-Guang Yan,Liangming Liu,Tao Li +8 more
TL;DR: In this article, the role of dynamin-related protein 1 (Drp1) in the adaptation of mitochondrial homeostasis to ischemic injury is not fully understood.
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Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock.
Chenyang Duan,Lei Kuang,Xiang Xinming,Jie Zhang,Yu Zhu,Yue Wu,Qing-Guang Yan,Liangming Liu,Tao Li +8 more
TL;DR: It is suggested that Drp1 activation perturbs the gut microbiome community and SCFA production in a ROS-specific manner and thereby substantially disturbs tight junctions and intestinal barrier function after hemorrhagic shock.
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Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2.
Chenyang Duan,Lei Kuang,Chen Hong,Xiang Xinming,Liu Jiancang,Qing-Hui Li,Xiaoyong Peng,Yuanqun Zhou,Hongchen Wang,Liangming Liu,Tao Li +10 more
TL;DR: In this paper, the authors performed a series of interaction and colocalization assays and found that the activation of dynamin-related protein 1 (Drp1) may promote the excessive opening of the mitochondrial permeability transition pore (mPTP) after hypoxia.
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A novel cross-linked haemoglobin-based oxygen carrier is beneficial to sepsis in rats
Lei Kuang,Yu Zhu,Jie Zhang,Yue Wu,Kunlun Tian,Xiangyun Chen,Mingying Xue,Fei Chuen Tzang,Billi Lau,Bing Lou Wong,Liangming Liu,Tao Li +11 more
TL;DR: YQ23 is a safe and effective resuscitation fluid for sepsis, and did not induce renal toxicity, severe oxidative effect and acute vasoconstriction, as well as prevent the vital organs injuries and improve the animal survival.
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Endothelial Microvesicles Induce Pulmonary Vascular Leakage and Lung Injury During Sepsis.
Danyang Zheng,Jie Zhang,Zisen Zhang,Lei Kuang,Yu Zhu,Yue Wu,Mingying Xue,Hongliang Zhao,Chenyang Duan,Liangming Liu,Tao Li +10 more
TL;DR: It is suggested that EMVs play an important role in pulmonary vascular leakage and lung injury during sepsis by transferring functional miR-23b andAntagonizing the secretion of EMVs and the miR -23b might be a potential target for the treatment of severe sepsi.