The journal of neuroscience : the official journal of the Society for Neuroscience.

The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in over a 1,000 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

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The Rotterdam Study: Objectives and design update

In this book Professor Holmes discusses some of the evidence relating to one of the most baffling problems yet recognized by biologists-the factors involved in the regulation of growth and form. A wide range of possible influences, from enzymes to cellular competition, is considered. Numerous experiments and theories are described, with or without bibliographic citation. There is a list of references for each chapter and an index. The subject from a scientific standpoint is an exceedingly difficult one, for the reason that very little indeed is understood regarding such phenomena as differentiation. It follows that the problem offers fine opportunities for intellectual jousting by mechanists and vitalists, that hypotheses and theories must often be the weapons of choice, and philosophy the armor. Professor Holmes gives us a good seat from which to watch the combats, explains clearly what is going on, and occasionally slips away to enter the lists himself. This stereoscopic atlas of anatomy was designed as an aid in teaching neuro-anatomy for beginning medical students and as a review for physicians taking Board examinations in Psychiatry and Neurology. Each plate consists of a pair of stereoscopic photographs and a labelled diagram of the important parts seen in the photograph. Perhaps in this day of scarcity of materials, particularly of human brains hardened for dissection, photographs of this kind conceivably can be used as a substitute. Successive stages of dissection are presented in such a fashion that, used in conjunction with the dissecting manual, a student should be able to identify most of the important components of the nervous system without much outside help. The area covered is limited to the gross features of the brain and brain stem and perhaps necessarily does not deal with any of the microscopic structure. So much more can be learned from the dissection of the actual brain that it is doubtful if this atlas would be useful except where brains are not available. A good deal of effort has been spent on the preparation of this atlas, with moderately successful results.

The Integrative Action of the Nervous System.

Background: The head impulse test (HIT) is a useful bedside test to identify peripheral vestibular deficits. However, such a deficit of the vestibulo-ocular reflex (VOR) may not be diagnosed because corrective saccades cannot always be detected by simple observation. The scleral search coil technique is the gold standard for HIT measurements, but it is not practical for routine testing or for acute patients, because they are required to wear an uncomfortable contact lens. Objective: To develop an easy-to-use video HIT system (vHIT) as a clinical tool for identifying peripheral vestibular deficits. To validate the diagnostic accuracy of vHIT by simultaneous measures with video and search coil recordings across healthy subjects and patients with a wide range of previously identified peripheral vestibular deficits. Methods: Horizontal HIT was recorded simultaneously with vHIT (250 Hz) and search coils (1,000 Hz) in 8 normal subjects, 6 patients with vestibular neuritis, 1 patient after unilateral intratympanic gentamicin, and 1 patient with bilateral gentamicin vestibulotoxicity. Results: Simultaneous video and search coil recordings of eye movements were closely comparable (average concordance correlation coefficient rc 0.930). Mean VOR gains measured with search coils and video were not significantly different in normal (p 0.107) and patients (p 0.073). With these groups, the sensitivity and specificity of both the reference and index test were 1.0 (95% confidence interval 0.69 –1.0). vHIT measures detected both overt and covert saccades as accurately as coils. Conclusions: The video head impulse test is equivalent to search coils in identifying peripheral vestibular deficits but easier to use in clinics, even in patients with acute vestibular neuritis. Neurology ® 2009;73:1134 –1141

The video head impulse test Diagnostic accuracy in peripheral vestibulopathy

Foundations of modern auditory theory

Background: Quantitative head impulse test (HIT) measures the gain of the angular vestibulo-ocular reflex (VOR) during head rotation as the ratio of eye to head acceleration. Bedside HIT identifies subsequent catch-up saccades after the head rotation as indirect signs of VOR deficit. Objective: To determine the VOR deficit and catch-up saccade characteristics in unilateral vestibular disease in response to HIT of varying accelerations. Methods: Eye and head rotations were measured with search coils during manually applied horizontal HITs of varying accelerations in patients after vestibular neuritis (VN, n = 13) and unilateral vestibular deafferentation (UVD, n = 15) compared to normal subjects (n = 12). Results: Normal VOR gain was close to unity and symmetric over the entire head-acceleration range. Patients with VN and UVD showed VOR gain asymmetry, with larger ipsilesional than contralesional deficits. As accelerations increased from 750 to 6,000 °/sec 2 , ipsilesional gains decreased from 0.59 to 0.29 in VN and from 0.47 to 0.13 in UVD producing increasing asymmetry. Initial catch-up saccades can occur during or after head rotation. Covert saccades during head rotation are most likely imperceptible, while overt saccades after head rotation are detectable by clinicians. With increasing acceleration, the amplitude of overt saccades in patients became larger; however, initial covert saccades also became increasingly common, occurring in up to about 70% of trials. Conclusions: Head impulse test (HIT) with high acceleration reveals vestibulo-ocular reflex deficits better and elicits larger overt catch-up saccades in unilateral vestibular patients. Covert saccades during head rotation, however, occur more frequently with higher acceleration and may be missed by clinicians. To avoid false-negative results, bedside HIT should be repeated to improve chances of detection.

Head impulse test in unilateral vestibular loss: vestibulo-ocular reflex and catch-up saccades

In 1988 we introduced impulsive testing of semicircular canal function measured with scleral search coils and showed that it could accurately and reliably detect impaired function even of a single lateral canal Later we showed that it was also possible to test individual vertical canal function in peripheral and also in central vestibular disorders, and proposed a physiological mechanism for why this might be so For the next 20 years, between 1988 and 2008, impulsive testing of individual semicircular canal function could only be accurately done by a few aficionados with the time and money to support scleral search coil systems – an expensive, complicated and cumbersome, semi-invasive technique that never made the transition from the research lab to the dizzy clinic Then in 2009 and 2013 we introduced a video method of testing function of each of the 6 canals individually Since 2009 the method has been taken up by most dizzy clinics around the world, with now close to 100 refereed articles in PubMed In many dizzy clinics around the world video Head Impulse Testing has supplanted caloric testing as the initial and in some cases the final test of choice in patients with suspected vestibular disorders Here we consider 7 current, interesting and controversial aspects of video Head Impulse Testing: 1 Introduction to the test; 2 the progress from the head impulse protocol (HIMPs) to the new variant – suppression head impulse protocol (SHIMPs); 3 The physiological basis for head impulse testing; 4 Practical aspects and potential pitfalls of video Head Impulse Testing; 5 Problems of vestibulo-ocular reflex gain calculations; 6 Head impulse testing in central vestibular disorders, and 7 To stay right up-to-date – new clinical disease patterns emerging from video head impulse testing With thanks and appreciation we dedicate this article to our friend, colleague and mentor, Dr Bernard Cohen of Mount Sinai Medical School, New York, who since his first article 55 years ago on compensatory eye movements induced by vertical semicircular canal stimulation, has become one of the giants of the vestibular world

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The Video Head Impulse Test.

Background/Hypothesis. The video Head Impulse Test (vHIT) is now widely used to test the function of each of the six semicircular canals individually by measuring the eye rotation response to an abrupt head rotation in the plane of the canal. The main measure of canal adequacy is the ratio of the eye movement response to the head movement stimulus i.e. the gain of the vestibulo-ocular reflex (VOR). However there is a need for normative data about how VOR gain is affected by age and also by head velocity, to allow the response of any particular patient to be compared to response of healthy subjects in their age range. In this study we determined for all six semicircular canals, normative values of VOR gain, for each canal across a range of head velocities, for healthy subjects in each decade of life. Study Design. The VOR gain was measured for all canals across a range of head velocities for at least 10 healthy subjects in decade age bands: 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, 80-89. Methods. The compensatory eye movement response to a small, unpredictable, abrupt head rotation (head impulse) was measured by the ICS Impulse prototype system. The same operator delivered every impulse to every subject. Results. VOR gain decreased at high head velocities, but was largely unaffected by age into the 80-89 year age group. There were some small but systematic differences between the two directions of head rotation, which appear to be largely due to the fact that in this study only the right eye was measured. The results are considered in relation to recent evidence about the effect of age on VOR performance. Conclusion. These normative values allow the results of any particular patient to be compared to the values of healthy people in their age range and so allow, for example, detection of whether a patient has a bilateral vestibular loss. VOR gain, as measured directly by the eye movement response to head rotation, seems largely unaffected by aging.

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The Video Head Impulse Test (vHIT) of Semicircular Canal Function - Age-Dependent Normative Values of VOR Gain in Healthy Subjects.

Taps to the forehead on the midline, at the hairline (Fz), with a reflex hammer or powerful bone conduction vibrator caused short-latency surface potentials from beneath both eyes in all healthy subjects. The earliest negative responses were invariably absent from the eye contralateral to the side of a previous vestibular nerve section but were preserved despite sensorineural hearing loss. These responses probably reflect vestibular function via crossed otolith–ocular pathways.

Leigh A. McGarvie

Papers

The video head impulse test Diagnostic accuracy in peripheral vestibulopathy

Head impulse test in unilateral vestibular loss: vestibulo-ocular reflex and catch-up saccades

The Video Head Impulse Test.

The Video Head Impulse Test (vHIT) of Semicircular Canal Function - Age-Dependent Normative Values of VOR Gain in Healthy Subjects.

Head taps evoke a crossed vestibulo-ocular reflex.