L
Leonard S. Rosenberg
Researcher at University of Rochester
Publications - 2
Citations - 117
Leonard S. Rosenberg is an academic researcher from University of Rochester. The author has contributed to research in topics: Cooperative binding & Binding site. The author has an hindex of 2, co-authored 2 publications receiving 116 citations.
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The antitumor agent mitoxantrone binds cooperatively to DNA: evidence for heterogeneity in DNA conformation.
TL;DR: A two-site model reproduces the observed binding isotherms and leads to the conclusion that DHAQ binds in clusters to selected regions of DNA, suggesting that clustering may play a role in the physiological activity of drugs.
Journal ArticleDOI
On the cooperative and noncooperative binding of ethidium to DNA.
TL;DR: No evidence of cooperative binding was observed in the binding isotherms obtained with calf thymus, C. perfringens, M. lysodeikticus, or poly(dG-dC), under the experimental conditions used (0.1 M NaCl).