Showing papers by "Leslie E. Orgel published in 2001"
TL;DR: This work has used amino acids activated by carbonyldiimidazole to study the enantiospecificity of peptide elongation in aqueous solution and found that in every case Ala3Glu10 was elongated more efficiently than Glu10.
Abstract: We have used amino acids activated by carbonyldiimidazole to study the enantiospecificity of peptide elongation in aqueoussolution Peptide `primers' Glu10 and Ala3Glu10were elongated with the enantiomers of arginine, glutamic acid,asparagine, phenylalanine, serine and valine The homochiral addition was always the more efficient reaction; the enantiospecificity was large in some cases but very small in others In every case Ala3Glu10 was elongated more efficiently than Glu10
9 citations
TL;DR: The synthesis of the beta-peptide 1 by the postsynthetic modification of the corresponding amino-containing peptide 3 is described and the potential of 1 to act as a template for the ligation of complementary negatively-charged peptides is discussed.
4 citations