Tabernaemontana L. (Apocynaceae): A review of its taxonomy, phytochemistry, ethnobotany and pharmacology☆

Chapter Two - Naturally Occurring Cyclotryptophans and Cyclotryptamines

The strychnine tree (Strychnos nux-vomica L.) (S. nux-vomica) belonging to family Loganiaceae has been a very promising medication for certain disorders. Different chromatographic methods were used to isolate the phenolic compounds from the aqueous methanolic extract of the S. nux-vomica leaves. Their identification was achieved through spectroscopic techniques. Cytotoxicity, analgesic, antipyretic and anti-inflammatory activities of S. nux-vomica leaves extract were evaluated. Five phenolic compounds were isolated and identified; Kaempferol-7 glucoside 1, 7-Hydroxy coumarin 2, Quercetin-3-rhamnoside 3, Kaempferol 3-rutinoside 4, and Rutin 5. Furthermore, the cytotoxic activity of the extract was evaluated against different cancer cell lines. The extract showed potential cytotoxic activity against human epidermoid larynx carcinoma cells (Hep-2) and against breast carcinoma cell line (MCF-7). Colon carcinoma cells (HCT) were the least one affected by the extract. In addition, the extract exhibited promising analgesic, antipyretic as well as anti-inflammatory activities. It is concluded that, leaves extract of S. nux vomica possess potent cytotoxic, analgesic, antipyretic and anti-inflammatory activities. These activities could be due to the presence of phenolic compounds revealed by our phytochemical investigations.

Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica

Medicinal uses, phytochemistry and pharmacology of Picralima nitida (Apocynaceae) in tropical diseases: a review.

Medicinal plants in tropical West Africa I. Plants acting on the cardiovascular system

[Alkaloids of Picralima nitida Stapf. V. Isolation of a new alkaloid: picraline].

[alkaloids from picralima nitida stapf, apocynaceae. 8. study of the leaves and roots. isolation of 2 new alkaloids: picraphylline and picracine].

Leaf alkaloids of Hunteria eburnea Pichon

[Alkaloids of Ervatamia pandacaqui Pichon (Tabernaemontana pandacaqui Poir.), Apocynaceae].

On the alkaloids of Tabernaemontana Pandacaqui Poir. (Apocynaceae)

Levy J

Papers

[Alkaloids of Picralima nitida Stapf. V. Isolation of a new alkaloid: picraline].

[alkaloids from picralima nitida stapf, apocynaceae. 8. study of the leaves and roots. isolation of 2 new alkaloids: picraphylline and picracine].

Leaf alkaloids of Hunteria eburnea Pichon

[Alkaloids of Ervatamia pandacaqui Pichon (Tabernaemontana pandacaqui Poir.), Apocynaceae].

On the alkaloids of Tabernaemontana Pandacaqui Poir. (Apocynaceae)