Showing papers by "Lina Bezdetnaya published in 1993"
TL;DR: It has been shown that Fe2+ ions and GSH activated PUVA haemolysis at both fluence rates of irradiation.
Abstract: The influence of Fe 2+ ions and reduced glutathione (GSH) on the haemolysis of erythrocytes photosensitized (366 nm) by psoralen (PUVA haemolysis) was investigated. PUVA haemolysis was induced by the low fluence rate (24 W m −2 ) and high fluence (greater than 150 W m −2 ) of UV-A irradiation. It has been shown that Fe 2+ ions and GSH activated PUVA haemolysis at both fluence rates of irradiation. PUVA haemolysis activation by Fe 2+ ions was more pronounced than that by GSH. It is supposed that activation caused by Fe 2+ ions and GSH is connected with their ability to reduce lipid peroxides or psoralen peroxides with the subsequent formation of free radicals. The regeneration of endogenous Fe 2+ by reduced glutathione is also possible.
8 citations