L
Lina E. Fortelius
Researcher at Åbo Akademi University
Publications - 5
Citations - 312
Lina E. Fortelius is an academic researcher from Åbo Akademi University. The author has contributed to research in topics: Keratin 8 & Keratin. The author has an hindex of 4, co-authored 5 publications receiving 275 citations.
Papers
More filters
Journal ArticleDOI
Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer
Veronika Mamaeva,Jessica M. Rosenholm,Laurel T. Bate-Eya,Lotta Bergman,Emilia Peuhu,Alain Duchanoy,Lina E. Fortelius,Sebastian K.-J. Landor,Diana M. Toivola,Mika Lindén,Cecilia Sahlgren +10 more
TL;DR: A novel approach, using imagable mesoporous silica nanoparticles (MSNPs) as vehicles for targeted delivery of GSIs to block Notch signaling is presented, highlighting MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application.
Journal ArticleDOI
Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism
Terhi O. Helenius,Julia O. Misiorek,Joel H. Nyström,Lina E. Fortelius,Aida Habtezion,Jian Liao,M. Nadeem Asghar,Haiyan Zhang,Salman Azhar,M. Bishr Omary,Diana M. Toivola +10 more
TL;DR: Ketogenic conditions fail to induce HMGCS2 in the keratin 8–knockout colon, suggesting a role for keratins in colonocyte energy homeostasis.
Journal ArticleDOI
Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway.
Iris A. K. Lähdeniemi,Julia O. Misiorek,Christian Antila,Sebastian K.-J. Landor,Sebastian K.-J. Landor,Carl-Gustaf A Stenvall,Lina E. Fortelius,Linda K Bergström,Cecilia Sahlgren,Diana M. Toivola,Diana M. Toivola +10 more
TL;DR: It is shown that K8 regulates Notch1 signalling activity and differentiation in the epithelium of the large intestine and can be rescued with re-expression of K8/K18 in K8-knockout CRISPR/Cas9 Caco-2 cells protein levels.
Journal ArticleDOI
The Amount of Keratins Matters for Stress Protection of the Colonic Epithelium
M. Nadeem Asghar,Jonas S. G. Silvander,Terhi O. Helenius,Iris A. K. Lähdeniemi,Catharina Alam,Lina E. Fortelius,Rickard O. Holmsten,Diana M. Toivola +7 more
TL;DR: The K8+/− mild colonic phenotype correlates with decreased keratin levels and increased sensitivity to experimental colitis, suggesting that a sufficient amount of keratin is needed for efficient stress protection in the colonic epithelia.