Linda Wiens

TL;DR: Results suggest that FLT images reflect TK(1) activity and the percentage of cells in S phase, and suggest that inhibition of cell cycle progression prevents FLT uptake and increased TK-1 activity.

TL;DR: Analysis of DNA methylation status of 27 genes on 49 paired cancerous and noncancerous tissue samples from non-small cell lung cancer patients who underwent surgical resection supported the hypothesis that the methylation of these two genes is a preneoplastic change and may be associated with tobacco smoking exposure.

TL;DR: Differences in NSCLC 18F-fluorodeoxyglucose uptake across histologic subtypes and differentiation groups parallel nearly identical differences in Ki-67 scores, implying that differences inNSCLC tumor cell proliferation may give rise to commensurate differences in tumor glucose metabolism.

TL;DR: As expected, tumor stage is prognostic in NSCLC, but tumor FDG uptake does not provide additional prognostic information, and SUV definitions based on lean body mass, body surface area, and plasma glucose correction yielded identical results.

TL;DR: Findings of differential gene hypermethylation frequencies in tumor tissues from patients with adenocarcinoma or squamous cell cancers and in females compared to males suggests that further investigation is warranted in order to more fully understand the potential disparate pathways and/or risk factors for NSCLC associated with histologic type and gender.