L
Lisa N. Henning
Researcher at Battelle Memorial Institute
Publications - 14
Citations - 202
Lisa N. Henning is an academic researcher from Battelle Memorial Institute. The author has contributed to research in topics: Bacillus anthracis & Obiltoxaximab. The author has an hindex of 7, co-authored 11 publications receiving 147 citations.
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Journal ArticleDOI
Obiltoxaximab Prevents Disseminated Bacillus anthracis Infection and Improves Survival during Pre- and Postexposure Prophylaxis in Animal Models of Inhalational Anthrax.
Brent J. Yamamoto,Annette M. Shadiack,Sarah Carpenter,Daniel C. Sanford,Lisa N. Henning,Nestor Gonzales,Edward O'Connor,Leslie S. Casey,Natalya V. Serbina +8 more
TL;DR: Prophylactic administration of obiltoxaximab before spore challenge or to spore-challenged animals before systemic bacterial dissemination is efficacious in promoting survival, ameliorating toxemia, and inhibiting bacterial spread to the periphery.
Journal ArticleDOI
Development of an Inhalational Bacillus anthracis Exposure Therapeutic Model in Cynomolgus Macaques
Lisa N. Henning,Jason E. Comer,Gregory V. Stark,Bryan D. Ray,Kevin P. Tordoff,Katherine A. B. Knostman,Gabriel T. Meister +6 more
TL;DR: The results support the use of the cynomolgus macaque as an appropriate therapeutic animal model for assessing the efficacy of medical countermeasures developed against anthrax when administered after a confirmation of infection.
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Efficacy Projection of Obiltoxaximab for Treatment of Inhalational Anthrax across a Range of Disease Severity.
Brent J. Yamamoto,Annette M. Shadiack,Sarah Carpenter,Daniel C. Sanford,Lisa N. Henning,Edward O'Connor,Nestor Gonzales,John Mondick,Jonathan French,Gregory V. Stark,Alan C. Fisher,Leslie S. Casey,Natalya V. Serbina +12 more
TL;DR: Overall, obiltsoxaximab monotherapy neutralized PA and increased survival across the range of disease severity, indicating clinical benefit of toxin neutralization with obiltoxximab in both early and late stages of inhalational anthrax.
Journal ArticleDOI
Characterization of a therapeutic model of inhalational anthrax using an increase in body temperature in New Zealand white rabbits as a trigger for treatment.
Jason E. Comer,Bryan D. Ray,Lisa N. Henning,Gregory V. Stark,Roy E. Barnewall,Jason M. Mott,Gabriel T. Meister +6 more
TL;DR: The increase in body temperature corresponded with both bacteremia and antigenemia (PA in the blood), indicating that SIBT is a suitable trigger to initiate treatment in a therapeutic model of inhalational anthrax.
Journal ArticleDOI
Pathophysiology of the Rhesus Macaque Model for Inhalational Brucellosis
Lisa N. Henning,Stephen M. Miller,Dennis H. Pak,Amber Lindsay,David A. Fisher,Roy E. Barnewall,Crystal M. Briscoe,Michael S. Anderson,Richard L. Warren +8 more
TL;DR: The results from this study support the use of the RM as an animal model for inhalational brucellosis to evaluate the efficacy of novel vaccines and therapeutics against B. melitensis.