L
Louis J. Magnotti
Researcher at University of Medicine and Dentistry of New Jersey
Publications - 33
Citations - 1900
Louis J. Magnotti is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Lung injury & Poison control. The author has an hindex of 21, co-authored 33 publications receiving 1749 citations. Previous affiliations of Louis J. Magnotti include University of Tennessee Health Science Center.
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Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock.
TL;DR: Gut barrier failure after hemorrhagic shock may be involved in the pathogenesis of shock-induced distant organ injury via gut-derived factors carried in the mesenteric lymph rather than the portal circulation.
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Burns, bacterial translocation, gut barrier function, and failure.
TL;DR: The goal of this review will be to provide a perspective on the evolution of the gut hypothesis of systemic inflammation and distant organ dysfunction.
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Temporary Abdominal Closure Techniques: A Prospective Randomized Trial Comparing Polyglactin 910 Mesh and Vacuum-Assisted Closure
Tiffany K. Bee,Martin A. Croce,Louis J. Magnotti,Ben L. Zarzaur,George O. Maish,Gayle Minard,Thomas J. Schroeppel,Timothy C. Fabian +7 more
TL;DR: MESH and VAC are both useful methods for abdominal coverage, and are equally likely to produce delayed primary closure, and neither method precludes secondary abdominal wall reconstruction.
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Gut-Derived Mesenteric Lymph A Link Between Burn and Lung Injury
TL;DR: The hypothesis that gut-derived factors carried in the mesenteric lymph contribute to burn-induced lung injury and may therefore play a role in postburn respiratory failure is supported and suggests that intestinal bacterial overgrowth primes the host such that when animals are exposed to a second stimulus (such as thermal injury) an exaggerated response occurs.
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Relationship between disruption of the unstirred mucus layer and intestinal restitution in loss of gut barrier function after trauma hemorrhagic shock.
Bobby Rupani,Francis J. Caputo,Anthony C. Watkins,Dennis Vega,Louis J. Magnotti,Qi Lu,Da Zhong Xu,Edwin A. Deitch +7 more
TL;DR: Studies of intestinal permeability documented that T/HS-induced loss of gut barrier function persisted throughout the 3-hour reperfusion period and were associated with injury to the mucus layer as well as the villi.