Showing papers by "Luis M. Ruilope published in 1984"
TL;DR: Ranitidine appears to interfere with aldosterone secretion in vivo, and plasma cortisol and prolactin levels were lower after ranitidine at the beginning of the test but their values were not significantly different after ambulation during ran itidine therapy.
Abstract: The effect of a 3-day oral course of ranitidine on plasma aldosterone level has been studied in 6 normotensive volunteers maintained in a state of sodium depletion. A significant fall in plasma aldosterone (p<0.05–0.02), in both the overnight recumbency levels and in the levels obtained during a two hour period of ambulation was observed. The change took place in the absence of variation in plasma renin activity and potassium. Plasma cortisol and prolactin levels were lower after ranitidine at the beginning of the test but their values were not significantly different after ambulation during ranitidine therapy. Ranitidine appears to interfere with aldosterone secretion in vivo.
9 citations
TL;DR: It is reported that the first case of congenital renal arteriovenous fistula in which renin-mediated arterial hypertension was the only clinical manifestation is reported.
6 citations
Journal Article•
TL;DR: It is concluded that PIH occurring in the second trimester is associated with elevated PRA, PA and blood pressure, and the inability of circulating ANG II to reduce PRA in PIH may constitute a major alteration underlying the pathophysiology of PIH.
Abstract: The hypothesis that pregnancy induced hypertension (PIH) is associated with abnormal physiological control of plasma renin activity (PRA) was tested by studying the effects of graded infusion of angiotensin II (ANG II) on PRA, plasma aldosterone (PA), and blood pressure in normal pregnancy, PIH, non-pregnant women in luteal and follicular phase of the menstrual cycle, and males. PIH occurring in the second trimester was associated with elevated PRA, PA and blood pressure compared with all other groups, and reduced urinary thromboxane excretion compared with normal pregnancy. Exogenous ANG II infusion failed to suppress existing PRA in patients with PIH, in contrast to all other groups, but increased PA in all groups. It is concluded that PIH occurring in the second trimester is associated with elevated PRA, PA and blood pressure. The inability of circulating ANG II to reduce PRA in PIH may constitute a major alteration underlying the pathophysiology of PIH.
3 citations
Journal Article•
TL;DR: The results show that the increase of plasma aldosterone after metoclopramide administration is independent of angiotensin II, ACTH and potassium, and that it increases even further due to the endogenous production of angiotsin II induced by postural changes.
Abstract: The influence of an increased endogenous production of angiotensin II and of sodium homeostasis upon the response of plasma aldosterone to metoclopramide administration has been investigated in 5 normal volunteers. Our results show that the increase of plasma aldosterone after metoclopramide administration is independent of angiotensin II, ACTH and potassium, and that it increases even further due to the endogenous production of angiotensin II induced by postural changes. The state of sodium balance seems to influence the response of plasma aldosterone to metoclopramide administration as it occurs with other stimuli of aldosterone secretion.
1 citations