Showing papers by "Luis M. Ruilope published in 1991"
TL;DR: Differences in the antiproteinuric effect of captopril, an antiotensin-converting enzyme inhibitor, are investigated; after 6 months of treatment, proteinuria decreased clearly in group I, whereas three patients in group II showed a worsening of renal function.
76 citations
45 citations
7 citations
TL;DR: Results seem to indicate that nitrendipine can be safely used in patients with arterial hypertension secondary to chronic renal parenchymatous disease.
Abstract: To test the tolerance to nitrendipine in arterial hypertension secondary to chronic renal parenchymatous disease, a group of 10 patients so diagnosed and adequately controlled with a diuretic alone or with a β-blocker were switched to nitrendipine at a dose to insure similarly adequate control of blood pressure. Patients were followed for 1 year at monthly intervals during which blood pressure measurement and the determination of a biochemical profile were performed
5 citations
TL;DR: Preliminary data seem to indicate that nitrendipine could be safely used in patients with arterial hypertension and chronic renal failure and that the effect of calcium-entry Mockers on the kidney facilitates its antihypertensive action.
Abstract: Calcium-entry blockers exert several characteristic effects on the kidney that potentiate their antihypertensive effect. Long-term therapy with nitrendipine, a dihydropyridine derivative, lowers blood pressure while maintaining renal hemodynamics within limits similar to pretreatment values in esential hypertension with normal renal function. This is accompanied by a persistent natriuretic effect that probably facilitates its antihypertensive action and is not followed by changes of the renin-angiotensin-aldosterone system
5 citations
TL;DR: It is shown that an increased concentration of calcium in renal circulation may induce a sequence of contrasting hemodynamics and excretory effects depending on the threshold of a particular mechanism that is first being stimulated.
3 citations