Varicoceles are vascular lesions of the pampiniform plexus and are the most common identifiable abnormality found in men being evaluated for infertility. Despite the long history associated with varicoceles, there remains much controversy regarding their diagnosis and management. The purpose of this manuscript is to address three of the most pressing controversies: (i) the association of varicoceles with male infertility, (ii) whether varicoceles exert a progressive deleterious effect and (iii) the relationship of varicocele size and outcome following varicocele repair. The current literature is reviewed in an effort to answer these questions. Based upon this analysis, conclusions can be drawn regarding the best management of varicoceles in subfertile men, adolescents, young fertile men and men with subclinical varicoceles. Although there remain many controversies due to a paucity of data, there appears to be a significant difference between adults and adolescents with respect to a progressive deterioration of semen parameters and it is clear that subclinical varicoceles do not play a major role in male infertility.

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Effects of varicocele on male fertility

The link between varicoceles and male infertility has been a matter of debate for more than half a century. Varicocele is considered the most common correctable cause of male infertility, but some men with varicoceles are able to father children, even without intervention. In addition, improvements in semen quality after varicocelectomy do not always result in spontaneous pregnancy. Studies regarding possible pathophysiological mechanisms behind varicocele-induced infertility have tried to address these controversies. Oxidative stress seems to be a central mechanism; however, no single theory is able to explain the differential effect of varicoceles on infertility. As a consequence, careful patient selection for treatment based on couple fertility status, varicocele grade, and semen quality is critical for achieving a chance of a subsequent pregnancy. A substantial amount of data on the effects of varicocelectomy has been gathered, but inadequate study design and considerable heterogeneity of available studies mean that these data are rarely conclusive. Current evidence suggests a beneficial effect of varicocelectomy on semen quality and pregnancy outcomes in couples with documented infertility only if the male partner has a clinically palpable varicocele and affected semen parameters.

Varicocele and male infertility

Comparison of outcomes of different varicocelectomy techniques: open inguinal, laparoscopic, and subinguinal microscopic varicocelectomy: a randomized clinical trial

https://www.europeanurology.com/article/S0302-2838(16)30396-7/pdf/varicocele-is-associated-with-impaired-semen-quality-and-reproductive-hormone-levels-a-study-of-7035-healthy-young-men-from-six-european-countries

Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries.

Are varicoceles associated with increased deoxyribonucleic acid fragmentation

Objective

 To evaluate semen quality and fecundity in a group of men with initially untreated varicocele testis, in comparison with control subjects.



Patients, subjects and methods

 In a prospective, longitudinal study, 77 men (39 with varicocele and 38 control subjects) were evaluated in 1989 and re-investigated after 8 years. Fifty-seven men (29 with varicocele, 28 controls) were available for evaluation and they all completed a questionnaire. Semen from a total of 46 men (24 with varicocele) was compared with findings in 22 men from the control group.



Results

 There was a decline in sperm count in the control group from 80×106 /mL to 55×106 /mL over the 8-year period, but nearly no change in the sperm count in the men with varicocele. The withdrawal rate from each group was the same and included both men with and without reduced semen quality. There were no differences between the groups in sperm motility values (straight-line velocity, curvilinear velocity) evaluated using computer-assisted semen analysis. Paternity was achieved by 10 of 14 men in the varicocele group, compared with 14 of 16 in the control group.



Conclusions

 There was no evidence that varicocelectomy might benefit patients, because the sperm concentration did not decline among men with varicocele over time. Computer-assisted semen analysis provided a good assessment of various sperm motility characteristics and we recommend evaluation using such objective methods, to allow comparison among studies

Lund

Papers

A follow-up study of semen quality and fertility in men with varicocele testis and in control subjects