The genus Amoora: A phytochemical and pharmacological review.

Three new inositol angelate compounds (1-3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4 and 5 exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC50 value at 8.4 and 13.2 μM. In addition, compounds 4 and 5 also showed remarkable growth inhibitory activity to Artemia salina larvae.

https://www.mdpi.com/1420-3049/25/5/1222/pdf

Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada.

Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities.

Five compounds were isolated from the EtOH extraction of the stem of Amoora dasyclada (How et T.Chen) C.Y.Wu (Meliaceae). On the basis of spectroscopic methods, their structures were elucidated as 24, 25-epoxy-tirucall-7-ene-3, 23-dione (1),24,25,26,27-tetranortirucall-7-ene-3-oxo-23(21)-Iactone (2),taraxerone (3),taraxerol (4)and β-sitosterol (5).Among them, compound 1 was a new triterpenoid, compounds 3-5 were firstly obtained from this plant; compound 2,an tetranortriterpenoid, was firstly isolated from natural sources, and its NMR data were assigned for the first time. Moreover, the △^7-bond and the Me-14 in compound 2 were never changed, which has never been found in other tetranortriterpenoids. And the biosynthetic pathway of tetranortriterpenoid was further discussed.

LUOXiao-Dong

Papers

A New Triterpenoid from Amoora dasyclada