Lusine Aghajanova

TL;DR: Integration of the miRNA and gene expression profiles provides unique insights into the molecular basis of this enigmatic disorder and, possibly, the regulation of the proliferative phenotype during the early secretory phase of the menstrual cycle in affected women.

TL;DR: The data support the eMSC as a clonogenic, multipotent pericyte that displays pathways of self-renewal and lineage specification, the potential to respond to conditions during endometrial desquamation and regeneration, and a genetic program predictive of its differentiated lineage, the stromal fibroblast.

TL;DR: DMSO as a cryoprotectant (at a 0.7 mol/l concentration) proved to maintain the structure of testicular tissue, especially spermatogonia, after cryopreservation better than PrOH or glycerol.

TL;DR: A meta-analysis of endometrial-receptivity associated genes is performed using a robust rank aggregation (RRA) method, followed by enrichment analysis, and regulatory microRNA prediction, which identifies 57 meta-signature genes and involved pathways that could serve as promising and sought-after biomarkers ofendometrial receptivity, fertility and infertility.

TL;DR: The dichotomy of 8-Br-cAMP regulation of select steroidogenic enzymes leading to an enriched E2 milieu within the endometrium and a blunted response of decidial biomarkers to this decidualizing agent of hESF from women with endometriosis suggests resistance to full decidUALization of the stromal fibroblasts and mechanisms underlying implantation failure and the pathophysiology of this disorder.