M
M.ª Dolores Mínguez Martínez
Researcher at Hospital Clínico San Carlos
Publications - 1
Citations - 244
M.ª Dolores Mínguez Martínez is an academic researcher from Hospital Clínico San Carlos. The author has contributed to research in topics: Glucose transporter & Receptor. The author has an hindex of 1, co-authored 1 publications receiving 203 citations.
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The expression of GLP‐1 receptor mRNA and protein allows the effect of GLP‐1 on glucose metabolism in the human hypothalamus and brainstem
Elvira Alvarez,M.ª Dolores Mínguez Martínez,Isabel Roncero,Julie A. Chowen,Beatriz García-Cuartero,Juan Domingo Gispert,Carmen Sanz,Patricia Vázquez,Antonio Maldonado,Javier de Cáceres,Manuel Desco,Miguel A. Pozo,Enrique Blázquez +12 more
TL;DR: Analysis of the PET studies revealed that the administration of GLP‐1(7–36) amide significantly reduced cerebral glucose metabolism in hypothalamus and brainstem, and the lower activity observed in these areas after peptide administration may be due to reduction of the glucose transport and/or glucose phosphorylation, which should modulate the glucose sensing process in the GLUT‐2‐ and GK‐containing cells.