Synthesis and characterization of novel palladium(II) complexes of bis(thiosemicarbazone). Structure, cytotoxic activity and DNA binding of Pd(II)-benzyl bis(thiosemicarbazonate).

The complexes [M(HL)L]ClO4(HL = methyl 2-pyridyl ketone thiosemicarbazone; M = Cu 1 or Co 2) have been prepared from the reaction of HL with the appropriate perchlorate salt; [Cu(HL)L]NCS 3 was also prepared by transmetallation of [Pb2(HL)L(NCS)2]NCS with an excess of copper(II) perchlorate. The new complexes have been characterized by spectroscopic techniques and the crystal structure of 3 has been determined: green triclinic crystal, a= 10.150(2), b= 10.350(2), c= 11.890(2)A, α= 88.55(3), β= 83.28(3), γ= 63.26(3)°, space group P, Z= 2. The copper atom is six-co-ordinated by two NNS donor sets from terdentate ligands.

Copper(II) and cobalt(II) complexes of methyl 2-pyridyl ketone thiosemicarbazone (HL); single-crystal structure of [Cu(HL)L]NCS

Synthesis and spectroscopic characterization of Schiff-base complexes of Cu(II), Ni(II), and Mn(II) resulting from condensation of salicylaldehyde derivatives with thiosemicarbazide [PHBT = 1-(5-(2-phenyldiazenyl)-2-hydroxybenzylidene)thiosemicarbazide, CHBT = 1-(5-(2-(2-chlorophenyl)diazenyl)-2-hydroxybenzylidene)thiosemicarbazide, and MHBT = 1-(5-(2-p-tolyldiazenyl)-2-hydroxybenzylidene)thiosemicarbazide] are discussed. The solid complexes were confirmed by elemental analysis (CHN), molar conductance, and mass spectra. Important infrared (IR) spectral bands corresponding to the active groups in the three ligands, 1H-NMR and UV-Vis spectra and thermogravimetric analysis were performed. The dehydration and decomposition of [Cu(PHBT)(H2O)], [Ni(PHBT)(H2O)] · 2H2O, [Mn(PHBT)(H2O)] · H2O, [Cu(CHBT)(H2O)], [Ni(CHBT)(H2O)] · H2O, [Mn(CHBT)(H2O)] · H2O, [Cu(MHBT)(H2O)], [Ni(MHBT)(H2O)] · 2H2O, and [Mn(MHBT)(H2O)] · 2H2O complexes were studied. The ligands are tridentate forming chelates with 1 : 1 (metal : liga...

Spectroscopic studies and biological evaluation of some transition metal complexes of Schiff-base ligands derived from 5-arylazo-salicylaldehyde and thiosemicarbazide

Polynuclear transition metal complexes with thiocarbohydrazide and dithiocarbamates

Thiohydrazone copper(II) complexes. The relationship between redox properties and superoxide dismutase mimetic activity.

Three benzil based, macrocyclic oxygen-, nitrogen-, and sulfur-containing ligands, (3,4,10,11-tetraphenyl-1,2,5,6,8,9,12,13-octaazacyclotetradeca-7,14-dithione-2,4,9,11-tetraene) ethanol (L 1 ), 10,11-diethoxy-3,4,10,11-tetraphenyl-1,2,5,6,8,9,12,13-octaazacyclotetradeca-7,14-dithione-2,4-diene (L 2 ), (3,4,10,11-tetraphenyl-1,2,5,6,8,9,12,13-octaazacyclotetradeca7,14-dione-2,4,9,11-tetraene) ethanol (L 3 ); a cyclic ligand, 6-ethoxy-1,6-diphenyl-4-oxo-3,4,5,6-tetrahydro-2,3,5-triazine (L 5 ) and two open chain ligands, benzilsemicarbazone (L 5 ) and benzilbisthiosemicarbazone (L 4 ) are reported

M. A. Mendiola

Papers

Copper(II) Complexes of Hydrazone Derivatives