Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized

Complexes of CuII, FeIII, CoII, NiII, TiIV and ZnII with 3,5-disubstituted salicylates, and ternary complexes of CuII containing substituted phenanthrolines have been prepared and characterised. The crystal structure of bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II), [Cu(phen)(Hdips)2], has been determined; CuII is in a tetragonal co-ordination environment with in-plane bonds to 2 nitrogens from phen[Cu–N 2.014(4)A] and 2 oxygens from the carboxylates of Hdips [Cu–O 1.951(3)A], with weaker off-axial bonds to carboxylate oxygens [Cu–O 2.557(3)A]. The hydroxyl oxygen of Hdips is not co-ordinated. These complexes have been tested for antiviral and cytotoxic activity. Most are potently cytotoxic, especially [Cu(dmphen)(Hdips)2], where dmphen is 2,9-dimethylphenanthroline.

Cytotoxicity and antiviral activity of transition-metal salicylato complexes and crystal structure of Bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II)

Phosphorane iminato complexes of main group elements

Superoxide dismutase activity of Cu(II)2(aspirinate)4 and its adducts with nitrogen and oxygen donors

Structures of molecules in the gas phase, determined experimentally, provide definitive information about their identity, reactivity and other properties, free from intermolecular interactions. Available methods have not been applicable to large and asymmetric molecules. Now the SARACEN (Structure Analysis Restrained by Ab initio Calculations for Electron diffractioN) method, using data from computational methods to complement experimental data, has opened the door to full structure determination for all sufficiently volatile molecules.

SARACEN – molecular structures from theory and experiment: the best of both worlds

Characterization of a mononuclear copper carboxylate complex: Bis(acetylsalicylato)bis(pyridine)copper(II)

Preparation des 2 composes du titre et de leurs composes d'addition avec le norbornadiene. Determination par diffraction RX des structures moleculaires de C 6 H 4 S 2 N 2 et des 2 composes d'addition. Les differences structurales entre C 6 H 4 S 2 N 2 et C 6 H 4 S 3 N 2 sont discutees a partir de calculs MNDO

Aromatic and antiaromatic thiazyl heterocycles. Comparison of the structural, spectroscopic, and cycloaddition properties of 1,3,2,4-benzodithiadiazine, C6H4S2N2, and 1,3,5,2,4-benzotrithiadiazepine, C6H4S3N2

The reaction of norbornadiene with (triphenylphosphoranediyl)aminocyclotrithiatriazene produces the cycloadduct Ph3PN—S3N3•C7H8. The crystal and molecular structure of this compound has been determ...

The cycloaddition of norbornadiene to (triphenylphosphoranediyl)aminocyclotrithiatriazene; the crystal and molecular structure of Ph3PN—S3N3•C7H8

Crystals of the title sulfur compound are orthorhombic, Cmca, with a=9.872 (1), b=9.594 (1), and c=15.488 (1) A, V=1467.0 (4) A3, Z=4, and Dc =1.38 g cm−2. The final refinement using 537 observed reflections for 57 variable gave R=0.025. The non-isomorphous crystals of the selenium analog are also orthorhombic, Cmca, with a=9.300 (1), b=19.724 (1), c=8.064 (1) A, V=1479.1 (4) A, Z=4, and Dc =2.21 g cm−2. Refinement with 48 variables using 447 observed reflections gives R=0.041. In both structures the molecules have 2/m symmetry imposed by the lattice symmetry; the S (or Se) atoms of the central 4-membered ring are located on the rotation axis, and the P, exo S (or Se), and two carbon atoms of the t-butyl group lie on the mirror plane. The central rings are not readily hydrolyzed or oxidized by exposure to air, apparently as a result of steric protection provided by the t-butyl groups.

CRYSTAL STRUCTURE OF T-BUTYL PERTHIOPHOSPHONIC ANHYDRIDE, (t-C4H9PS2)2, AND ITS SELENIUM ANALOG (t-C4H9PSe2)2

Synthesis of (1Z, 3Z)-1, 4-dibromobutadiene, (1Z, 3Z)-1-bromo-4-lithiobutadiene and (1Z, 3Z)-1, 4-dilithiobutadiene; structure of (1Z, 3Z)-(η5-C5H5)Fe(CO)2CH=CHCH=CHBr

M. C. Noble

Papers

Characterization of a mononuclear copper carboxylate complex: Bis(acetylsalicylato)bis(pyridine)copper(II)

Aromatic and antiaromatic thiazyl heterocycles. Comparison of the structural, spectroscopic, and cycloaddition properties of 1,3,2,4-benzodithiadiazine, C6H4S2N2, and 1,3,5,2,4-benzotrithiadiazepine, C6H4S3N2

The cycloaddition of norbornadiene to (triphenylphosphoranediyl)aminocyclotrithiatriazene; the crystal and molecular structure of Ph3PN—S3N3•C7H8

CRYSTAL STRUCTURE OF T-BUTYL PERTHIOPHOSPHONIC ANHYDRIDE, (t-C4H9PS2)2, AND ITS SELENIUM ANALOG (t-C4H9PSe2)2

Synthesis of (1Z, 3Z)-1, 4-dibromobutadiene, (1Z, 3Z)-1-bromo-4-lithiobutadiene and (1Z, 3Z)-1, 4-dilithiobutadiene; structure of (1Z, 3Z)-(η5-C5H5)Fe(CO)2CH=CHCH=CHBr