M
M. Cordier-Bussat
Publications - 1
Citations - 53
M. Cordier-Bussat is an academic researcher. The author has contributed to research in topics: Insulin receptor & Receptor. The author has an hindex of 1, co-authored 1 publications receiving 49 citations.
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An arginine to cysteine252 mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events
Isabelle Hamer,Michelangelo Foti,R. Emkey,M. Cordier-Bussat,J. Philippe,P De Meyts,Christine Maeder,C R Kahn,Jean-Louis Carpentier +8 more
TL;DR: Observations suggest that parameters other than tyrosine kinase activation participate in or control the first steps of IR internalisation or both; IR-mediated IRS 1/2 phosphorylation can be achieved from the cell surface and microvilli in particular and defective IR endocytosis correlates with an enhancement of some biological responses to insulin and attenuation of others.