Use of activation methods for organozinc reagents

A simple and highly efficient synthesis of β-amino-α, β-unsaturated ester via sonochemical Blaise reaction

Homoenolates and other functionalized organometallics. a review

The Reformatsky reaction is the reaction of an α-halo ester with an aldehyde or ketone in the presence of zinc metal as shown in Scheme 1. The usual product of the reaction is a (β-hydroxy ester, which may be dehydrated in subsequent steps to give an unsaturated ester. A zinc ester enolate (1), the so-called Reformatsky reagent, is an intermediate in the reaction and the sequence is thus classified as an aldol condensation. Compared to the usual base-promoted aldol procedures, the distinguishing features of the Reformatsky reaction are the use of a metal-halogen redox reaction rather than an acid-base reaction to form the enolate, and the fact that the counterion of the enolate is zinc.

1.8 – Zinc Enolates: the Reformatsky and Blaise Reactions

Bis(triméthylsiloxy)-1,1 butadiène-1,3 et triméthylsilyl-4 butène-2 oate de triméthylsilyle: préparations et réactions avec le benzaldéhyde

Sur la regio selectivite de la reaction du benzaldehyde avec les organozinciques issus du γ-bromocrotonate et du γ-bromosenecioate de trimethylsilyle

Iminoethers of type 1 have been shown to react with organometallic reagents to give oxazolines in good yield. The process of the reaction is discussed.

Action des Organométalliques sur les Iminoéthers: Nouvelle Voie D'Accès Aux Oxazolines

A New Convenient Laboratory Synthesis of Trimethylsilyl Bromide

Both Z et E γ-bromosenecioic trimethylsilyl esters react with s-cyclocitral in the presence of zinc and at low temperature (−40°C) to give the hydroxyacid 2 as the main product. When the reaction is carried out at reflux of THF for 30 mn, the lactone 4 is exclusively obtained. An extended heating of the reaction mixture leads to the acid 5.

M. Gaudemar

Papers

Sur la regio selectivite de la reaction du benzaldehyde avec les organozinciques issus du γ-bromocrotonate et du γ-bromosenecioate de trimethylsilyle

Action des Organométalliques sur les Iminoéthers: Nouvelle Voie D'Accès Aux Oxazolines

A New Convenient Laboratory Synthesis of Trimethylsilyl Bromide

Stereochimie De La Reaction Du β‐Cyclocitral Avec Les Organozinciques Issus Des γ‐Bromosenecioates De Trimethylsilyle